Evidence map›Paper›PMID 29311094›Full record

ArticleAntimicrobial agents and chemotherapy2018

Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II, and III) Adult Subjects.

Kristen L Bunnell, Manjunath P Pai, Monica Sikka, Susan C Bleasdale, Eric Wenzler, Larry H Danziger, Keith A Rodvold

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristen L BunnellUniversity of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA.ORCID 0000-0002-7646-0594
Manjunath P PaiUniversity of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
Monica SikkaUniversity of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Susan C BleasdaleUniversity of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Eric WenzlerUniversity of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA.ORCID 0000-0003-3914-8400
Larry H DanzigerUniversity of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA.
Keith A RodvoldUniversity of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA kar@uic.edu.

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
NCATS NIH HHS UL1 TR002003
6 · The paper itself

Abstract

A recommended total-body-weight (TBW) dosing strategy for telavancin may not be optimal in obese patients. The primary objective of this study was to characterize and compare the pharmacokinetics (PK) of telavancin across four body size groups: normal to overweight and obese classes I, II, and III. Healthy adult subjects (

Indexed as

AminoglycosidesAnti-Bacterial AgentsBody WeightHumansIdeal Body WeightLipoglycopeptidesModels, TheoreticalObesityStaphylococcal InfectionsAminoglycosidesAnti-Bacterial AgentsLipoglycopeptidestelavancinobesitypharmacokineticstelavancin

Identifiers

PMID29311094
PMCPMC5913990

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.