Evidence map›Paper›PMID 29311077›Full record

ArticleAntimicrobial agents and chemotherapy2018

Posaconazole Tablets in Real-Life Lung Transplantation: Impact on Exposure, Drug-Drug Interactions, and Drug Management in Lung Transplant Patients, Including Those with Cystic Fibrosis.

Manon Launay, Antoine Roux, Laurence Beaumont, Benoit Douvry, Lucien Lecuyer, Emmanuel Douez, Clément Picard, Dominique Grenet, Vincent Jullien, Véronique Boussaud and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Drug Interactions between Antimicrobial and Immunosuppressive Agents in Solid Organ Transplant Recipients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Review
  6. Review
  7. A Peculiar Case of Pneumonia due toPathogens (Basel, Switzerland) · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Manon LaunayLaboratory of Pharmacology and Toxicology, European Hospital Georges Pompidou-APHP, Paris, France manon.launay@aphp.fr Eliane.billaud@aphp.fr.ORCID 0000-0003-3113-7301
Antoine RouxPneumology, Adult Cystic Fibrosis Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Laurence BeaumontPneumology, Adult Cystic Fibrosis Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Benoit DouvryPneumology, Adult Cystic Fibrosis Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Lucien LecuyerThoracic Transplantation, European Hospital Georges Pompidou-APHP, Paris, France.
Emmanuel DouezLaboratory of Pharmacology and Toxicology, European Hospital Georges Pompidou-APHP, Paris, France.
Clément PicardPneumology, Adult Cystic Fibrosis Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Dominique GrenetPneumology, Adult Cystic Fibrosis Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Vincent JullienLaboratory of Pharmacology and Toxicology, European Hospital Georges Pompidou-APHP, Paris, France.
Véronique BoussaudThoracic Transplantation, European Hospital Georges Pompidou-APHP, Paris, France.
Romain GuillemainThoracic Transplantation, European Hospital Georges Pompidou-APHP, Paris, France.
Eliane M BillaudLaboratory of Pharmacology and Toxicology, European Hospital Georges Pompidou-APHP, Paris, France manon.launay@aphp.fr Eliane.billaud@aphp.fr.
Assistance Publique – Hôpitaux de Paris · FRHôpital Foch · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Appropriate exposure to posaconazole (PSZ) has been limited until the recent approval of the delayed-release oral tablet formulation. Our goal was to determine the exposure obtained by using the standard dose of 300 mg once a day in lung transplant (LT) patients, including patients with cystic fibrosis (CF). PSZ trough concentrations (

Indexed as

Lung TransplantationAdultAgedAntifungal AgentsAspergillusCystic FibrosisDrug Administration ScheduleDrug InteractionsEverolimusFemaleHumansImmunosuppressive AgentsInvasive Pulmonary AspergillosisMaleMiddle AgedProspective StudiesAntifungal AgentsEverolimusImmunosuppressive AgentsposaconazoleTabletsTacrolimusTriazolescystic fibrosisdrug-drug interactionlung transplantationposaconazole tabletsproton pump inhibitors

Identifiers

PMID29311077
PMCPMC5826104
OpenAlexW2782502852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.