Evidence map›Paper›PMID 29311070›Full record

ArticleAntimicrobial agents and chemotherapy2018

Novel Pyrimidines as Antitubercular Agents.

Daigo Inoyama, Steven D Paget, Riccardo Russo, Srinivasan Kandasamy, Pradeep Kumar, Eric Singleton, James Occi, Margareta Tuckman, Matthew D Zimmerman, Hsin Pin Ho and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Evolution of Small Molecule Inhibitors ofJournal of medicinal chemistry · 2025
    Article
  4. Review
  5. Review
  6. Small Molecule Benzothiophene withJournal of medicinal chemistry · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. ACS infectious diseases · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Random Forest Model Prediction of Compound Oral Exposure in the Mouse.ACS pharmacology & translational science · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Daigo Inoyama *Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Steven D Paget *Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Riccardo RussoDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Srinivasan KandasamyDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Pradeep KumarDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Eric SingletonDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
James OcciDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Margareta TuckmanDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Matthew D ZimmermanPublic Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Hsin Pin HoPublic Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Alexander L PerrymanDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Véronique DartoisPublic Health Research Institute, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Nancy ConnellDivision of Infectious Disease, Department of Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.
Joel S FreundlichDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA freundjs@rutgers.edu.
Rutgers, The State University of New Jersey · USRutgers New Jersey Medical School

Funding

Therapeutics for drug resistant-bacteria: Arylpropionyl-phloroglucinolsU19AI109713 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI LU, MIN · 2014 to 2018
$26.9M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
NIAID NIH HHS U19 AI109713NIH HHS S10 OD023524
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug DesignAnimalsAntitubercular AgentsDisease Models, AnimalDrug StabilityFemaleHumansMiceMicrobial Sensitivity TestsMycobacterium tuberculosisNitroimidazolesPyrimidinesSolubilityStructure-Activity RelationshipTuberculosisAntitubercular AgentsNitroimidazolespretomanidPyrimidinesantitubercularMycobacterium tuberculosispharmacokineticspyrimidine

Identifiers

PMID29311070
PMCPMC5826157
OpenAlexW2782111507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.