Evidence map›Paper›PMID 29311053›Full record

Trial reportCirculation2018

Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention.

Erin J Howden, Satyam Sarma, Justin S Lawley, Mildred Opondo, William Cornwell, Douglas Stoller, Marcus A Urey, Beverley Adams-Huet, Benjamin D Levine

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02039154 (The Effect of Long Duration Exercise on the Diastolic Function of the Heart), which is not on this map. Cited by 98 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 5 pooled it
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02039154 nacompletednot on this map

The Effect of Long Duration Exercise on the Diastolic Function of the Heart

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2012 to 2016Enrolled61ConditionsAgingArmsAerobic and strength training group, Balance and flexibility group
3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 5 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  3. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Erin J HowdenInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Satyam SarmaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Justin S LawleyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Mildred OpondoInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
William CornwellInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Douglas StollerInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Marcus A UreyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Beverley Adams-HuetUniversity of Texas Southwestern Medical Center, Dallas (E.J.H., S.S., J.S.L., D.S., M.A.U., B.A.-H., B.D.L.).
Benjamin D LevineInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.). benjaminlevine@texashealth.org.
Texas Health Dallas · USBaker Heart and Diabetes Institute · AUThe University of Texas Southwestern Medical Center · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Aging Fitness & Failure: Mechanisms of Diastolic DysfunctionR01AG017479 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BENJAMIN D · 2001 to 2016
$7.8M
Effect of Mechanical Circulatory Support on Exercise Capacity in Heart FailureK23HL132048 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CORNWELL, WILLIAM · 2016 to 2020
$819k
NCATS NIH HHS UL1 TR001105NHLBI NIH HHS K23 HL132048NIA NIH HHS R01 AG017479
6 · The paper itself

Abstract

backgroundPoor fitness in middle age is a risk factor for heart failure, particularly heart failure with a preserved ejection fraction. The development of heart failure with a preserved ejection fraction is likely mediated through increased left ventricular (LV) stiffness, a consequence of sedentary aging. In a prospective, parallel group, randomized controlled trial, we examined the effect of 2 years of supervised high-intensity exercise training on LV stiffness.

methodsSixty-one (48% male) healthy, sedentary, middle-aged participants (53±5 years) were randomly assigned to either 2 years of exercise training (n=34) or attention control (control; n=27). Right heart catheterization and 3-dimensional echocardiography were performed with preload manipulations to define LV end-diastolic pressure-volume relationships and Frank-Starling curves. LV stiffness was calculated by curve fit of the diastolic pressure-volume curve. Maximal oxygen uptake (Vo

resultsFifty-three participants completed the study. Adherence to prescribed exercise sessions was 88±11%. Vo

conclusionsIn previously sedentary healthy middle-aged adults, 2 years of exercise training improved maximal oxygen uptake and decreased cardiac stiffness. Regular exercise training may provide protection against the future risk of heart failure with a preserved ejection fraction by preventing the increase in cardiac stiffness attributable to sedentary aging. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02039154.

Indexed as

High-Intensity Interval TrainingMyocardial ContractionRisk Reduction BehaviorSedentary BehaviorVentricular Function, LeftAge FactorsCardiac CatheterizationCardiorespiratory FitnessEchocardiography, Three-DimensionalFemaleHeart FailureHumansMaleMiddle AgedOxygen ConsumptionProspective Studiescatheterizationdiastoleexercisehumansmonitoring, physiologicalprevention & controlventricular functionventricular remodeling

Identifiers

PMID29311053
PMCPMC5893372
OpenAlexW2781868410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.