Evidence map›Paper›PMID 29310988›Full record

ReviewParkinsonism & related disorders2018

An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group.

Ivan Rektor, Nicolaas I Bohnen, Amos D Korczyn, Viktoria Gryb, Hrishikesh Kumar, Milica G Kramberger, Frank-Erik de Leeuw, Zvezdan Pirtošek, Irena Rektorová, Ilana Schlesinger and 3 more

Abstract readReview
In one paragraph

Review in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Discriminating vascular parkinsonism from early-stage postural instability gait difficulty subtype dominant Parkinson's disease: a dual-task gait analysis using wearable sensors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  4. Vascular parkinsonism: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
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  10. Review
  11. Multiple system atrophy.Practical neurology · 2023
    Review
  12. Review
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  16. Pain in atypical parkinsonism, vascular parkinsonism, and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ivan RektorMasaryk University, Central European Institute of Technology - CEITEC, Neuroscience Centre and Movement Disorders Centre, Brno, Czech Republic. Electronic address: irektor@med.muni.cz.
Nicolaas I BohnenDepartments of Radiology and Neurology, University of Michigan, and Ann Arbor VA Medical Center, Ann Arbor, MI, USA.
Amos D KorczynDepartment of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
Viktoria GrybIvano-Frankivsk Medical University, Department of Neurology and Neurosurgery, Ivano-Frankivsk Regional Hospital, Vascular Neurology Department, Ivano-Frankivsk, Ukraine.
Hrishikesh KumarDepartment of Neurology, Institute of Neurosciences, Kolkata, India.
Milica G KrambergerDepartment of Neurology, University Medical Centre, Ljubljana, Slovenia.
Frank-Erik de LeeuwRadboud University Nijmegen Medical Center, Donders Institute Brain Cognition & Behaviour, Center for Neuroscience Department of Neurology, Nijmegen, The Netherlands.
Zvezdan PirtošekDepartment of Neurology, University Medical Centre, Ljubljana, Slovenia.
Irena RektorováMasaryk University, Central European Institute of Technology - CEITEC, Neuroscience Centre and Movement Disorders Centre, Brno, Czech Republic.
Ilana SchlesingerDepartment of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, Israel.
Jaroslaw SlawekNeurology Department, St. Adalbert Hospital, Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Gdansk, Poland.
Peter Valkovič2nd Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Branislav VeselýDepartment of Neurology, Hospital Nitra, Slovak Republic.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREY, KIRK A. · 1985 to 2012
$13.0M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
IMAGING BIOMARKERS OF PROGRESSION OF MOBILITY IMPAIRMENT IN PDI01RX000317 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2012 to 2014
–
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
A Pilot Tolerance Study of Dynamic Stepping Compared To Static Standing in PDI21RX001587 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2015 to 2016
–
NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS070856RRD VA I01 RX000317RRD VA I01 RX001631RRD VA I21 RX001587
6 · The paper itself

Abstract

This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non-motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows for the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenerative parkinsonisms. Directions for future research are also discussed.

Indexed as

Practice Guidelines as TopicCerebrovascular DisordersCognitive DysfunctionDementiaDiagnosis, DifferentialGait Disorders, NeurologicHumansParkinsonian DisordersReview Literature as TopicRisk FactorsSyndromeBinswanger's diseaseCerebrovascular diseaseGaitImagingVascular parkinsonism

Identifiers

PMID29310988
PMCPMC5857227

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.