ArticleOphthalmology2018
Glaucomatous Optic Neuropathy Associated with Nocturnal Dip in Blood Pressure: Findings from the Maracaibo Aging Study.
Article in Ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Timing of antihypertensive medication (bedtimeFrontiers in pharmacology · 2026Pooled it
- The Relevance of Arterial Blood Pressure in the Management of Glaucoma Progression: A Systematic Review.American journal of hypertension · 2024Pooled it
- High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.Investigative ophthalmology & visual science · 2022Pooled it
- Relationship between long-term blood pressure fluctuations and visual field progression in primary open-angle glaucoma: a prospective cohort study.Eye and vision (London, England) · 2026Article
- Controversies in hypertension therapy: bedtime dosing or daytime dosing?Journal of hypertension · 2025Review
- Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics.BMC ophthalmology · 2025Article
- Predictive modeling of rapid glaucoma progression based on systemic data from electronic medical records.Scientific reports · 2025Article
- Systolic blood pressure time in target range within 24 hours and incident heart failure: insights from the real-world setting.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Article
- 24-Hour Blood Pressure Patterns in NAION: Exploring the Impact of Dipping Classifications and Comorbidities.Neuro-ophthalmology (Aeolus Press) · 2025Article
- Association of Age of Menopause and Glaucoma Diagnosis in Female Veterans.Investigative ophthalmology & visual science · 2024Article
- Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease.Journal of clinical medicine · 2024Review
- TIME to discuss the optic nerve?Eye (London, England) · 2023Article
- Open-Angle Glaucomatous Optic Neuropathy Is Related to Dips Rather Than Increases in the Mean Arterial Pressure Over 24-H.American journal of hypertension · 2022Article
- The Role of Axonal Transport in Glaucoma.International journal of molecular sciences · 2022Review
- Progression of functional and structural glaucomatous damage in relation to diurnal and nocturnal dips in mean arterial pressure.Frontiers in cardiovascular medicine · 2022Article
- Comparison of Two Tonometers in the Evaluation of 24-Hour Intraocular Pressure and Mean Ocular Perfusion Pressure in Patients with Thyroid-Associated Ophthalmopathy.Journal of ophthalmology · 2022Article
- Association of morning blood pressure surge with chronic kidney disease progression in patients with chronic kidney disease and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Observational
- U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects.Investigative ophthalmology & visual science · 2021Article
- Association between vascular comorbidity and glaucoma progression: A four-year observational study.Experimental and therapeutic medicine · 2021Article
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17 authors.
Funding
Abstract
purposeTo determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics.
designObservational cross-sectional study.
participantsA subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure <22 mmHg.
methodsUnivariate and multivariate logistic regression analyses under the generalized estimating equations (GEE) framework were used to examine the relationships between glaucomatous damage and BP parameters, with particular attention to decreases in nocturnal BP.
main outcome measuresGlaucomatous optic neuropathy (GON) based on the presence of optic nerve damage and VF defects.
resultsThe mean age was 61.9 years, and 87.1% were women. Of 185 eyes evaluated, 19 (26.5%) had signs of GON. Individuals with GON had significantly lower 24-hour and nighttime diastolic BP levels than those without. However, results of the multivariate GEE models indicated that the glaucomatous damage was not related to the average systolic or diastolic BP levels measured over 24 hours, daytime, or nighttime. In contrast, extreme decreases in nighttime systolic and diastolic BP (>20% compared with daytime BP) were significant risk factors for glaucomatous damage (odds ratio, 19.78 and 5.55, respectively).
conclusionsIn this population, the link between nocturnal BP and GON is determined by extreme dipping effects rather than low nocturnal BP levels alone. Further studies considering extreme decreases in nocturnal BP in individuals at high risk of glaucoma are warranted.
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