ArticleSchizophrenia research2018
Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Disturbed Functional Connectivity Between Anterior Default Mode and Sensory Processing Regions Is Linked to Peripheral Inflammatory Markers and Psychopathology in Schizophrenia.Schizophrenia bulletin · 2026Article
- Functional Connectivity Changes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Graph-Theoretic and Topology-Based Study.Brain and behavior · 2025Article
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- Altered temporal lobe connectivity is associated with psychotic symptoms in drug-naïve adolescent patients with first-episode schizophrenia.European child & adolescent psychiatry · 2025Article
- Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri.Frontiers in human neuroscience · 2025Article
- Abnormal temporal variability of rich-club organization in three major psychiatric conditions.Frontiers in psychiatry · 2023Article
- Youth with Down syndrome display widespread increased functional connectivity during rest.Scientific reports · 2022Article
- Abnormal global-brain functional connectivity and its relationship with cognitive deficits in drug-naive first-episode adolescent-onset schizophrenia.Brain imaging and behavior · 2022Article
- Alterations in functional network centrality in first-episode drug-naïve adolescent-onset schizophrenia.Brain imaging and behavior · 2022Article
- Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study.NeuroImage. Clinical · 2022Article
- Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia.NeuroImage. Clinical · 2022Article
- Current methods and new directions in resting state fMRI.Clinical imaging · 2020Review
- Article
- The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.Nature communications · 2019Article
- Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.Biological psychiatry · 2019Article
- Overt social interaction and resting state in young adult males with autism: core and contextual neural features.Brain : a journal of neurology · 2019Article
- A Connectomic Atlas of the Human Cerebrum-Chapter 1: Introduction, Methods, and Significance.Operative neurosurgery (Hagerstown, Md.) · 2018Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChildhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients and their siblings exhibit similar abnormalities of functional connectivity.
methodsA whole-brain, data-driven approach was used to assess resting-state functional connectivity differences in COS (patients/siblings/controls, n: 26/28/33) and AOS (n: 19/28/30). There were no significant differences in age, sex, or head motion across groups in each dataset and as designed, the COS dataset has a significantly lower age than the AOS.
resultsBoth COS and AOS patients showed decreased functional connectivity relative to controls among a wide set of brain regions (P<0.05, corrected), but their siblings did not. Decreased connectivity in COS and AOS patients showed no amplitude differences and was not modulated by age-at-onset or medication doses. Cluster analysis revealed that these regions fell into two large-scale networks: one sensorimotor network and one centered on default-mode network regions, but including higher-order cognitive areas only in COS. Decreased connectivity between these two networks was notable (P<0.05, corrected) for both patient groups.
conclusionsA shared pattern of attenuated functional connectivity was found in COS and AOS, supporting the continuity of childhood-onset and adult-onset schizophrenia. Connections were altered between sensorimotor areas and default-mode areas in both COS and AOS, suggesting potential abnormalities in processes of self-monitoring and sensory prediction. The absence of substantial dysconnectivity in siblings indicates that attenuation is state-related.
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Registered trials
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