ArticleEpidemiology and infection2018
Population-based seroprevalence of Puumala hantavirus in Finland: smoking as a risk factor.
Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Seroprevalence of hantavirus infection in non-epidemic settings over four decades: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Epidemiological and clinical characteristics of death from hemorrhagic fever with renal syndrome: a meta-analysis.Frontiers in microbiology · 2024Pooled it
- Hantavirus Seroprevalence in the Population of Saint Petersburg and the Leningrad Region, Russia.Viruses · 2026Article
- Association of iron metabolism with disease severity in acute Puumala hantavirus infection.BMC nephrology · 2025Article
- Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.Human molecular genetics · 2025Article
- Seroprevalence of Hantavirus among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil.Viruses · 2023Article
- Article
- Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.Viruses · 2022Article
- Article
- Long-Term Consequences of Puumala Hantavirus Infection.Viruses · 2022Article
- Alcohol Consumption and Its Influence on the Clinical Picture of Puumala Hantavirus Infection.Viruses · 2022Article
- Article
- Article
- Review
- Epidemiology of hemorrhagic fever with renal syndrome in Tai'an area.Scientific reports · 2021Article
- Analysis of Hemorrhagic Fever With Renal Syndrome Using Wavelet Tools in Mainland China, 2004-2019.Frontiers in public health · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights. In total, 254 sera among 2000 tested were PUUV-IgG-positive resulting in a weighted seroprevalence of 12.5%, (95% CI 10.9-14.4), mirroring known age and regional variation in reported incidence. No associations between PUUV-seropositivity and chronic diseases including cardiovascular (including hypertension), pulmonary, kidney disease and cancer were observed. Smoking was significantly associated with seropositivity (adjusted OR 1.54; 95% CI 1.16-2.04). In addition, significant dose-response relations were found for the number of cigarettes smoked daily (OR 1.14; 95% CI 1.12-1.28). The results are important for disease burden assessment and guide intervention strategies, highlighting also the role of smoking prevention.
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