Evidence map›Paper›PMID 29310723›Full record

ArticleActa neuropathologica communications2018

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study.

Ignazio Cali, Mark L Cohen, Stephane Haik, Piero Parchi, Giorgio Giaccone, Steven J Collins, Diane Kofskey, Han Wang, Catriona A McLean, Jean-Philippe Brandel and 13 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 120 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
  6. 1-L Transcription in Prion Diseases.International journal of molecular sciences · 2024
    Article
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  13. Review
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  18. Article
  19. Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 5 countries.

Ignazio CaliDepartments of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. ixc20@case.edu.
Mark L CohenDepartments of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Stephane HaikInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France.
Piero ParchiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Giorgio GiacconeFondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
Steven J CollinsAustralian National Creutzfeldt-Jakob Disease Registry, Department of Medicine, and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Australia.
Diane KofskeyDepartments of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Han WangDepartment of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Catriona A McLeanDepartment of Anatomical Pathology, Alfred Health, Melbourne, 3181, Australia.
Jean-Philippe BrandelInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France.
Nicolas PrivatInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France.
Véronique SazdovitchInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France.
Charles DuyckaertsInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris VI UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France.
Tetsuyuki KitamotoDepartment of Neurological Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ermias D BelayDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Ryan A MaddoxDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Fabrizio TagliaviniFondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
Maurizio PocchiariDepartment of Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Ellen LeschekNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Brian S ApplebyDepartments of Neurology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Jiri G SafarDepartments of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Lawrence B SchonbergerDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Pierluigi GambettiDepartments of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. pxg13@case.edu.
Centre National de la Recherche Scientifique · FRUniversity School · USCenters for Disease Control and Prevention · USCase Western Reserve University · USFondazione IRCCS Istituto Neurologico Carlo Besta · ITFlorey Institute of Neuroscience and Mental Health · AUInstitute of Neurological Sciences · ITIstituto Superiore di Sanità · ITNational Institutes of Health · USThe University of Melbourne · AUTohoku University · JPUniversity Hospitals of Cleveland · US

Funding

Neuropathology Core - P GambettiP01AI106705 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI · 2014 to 2018
$7.7M
Characterization of Rapidly Progressive Alzheimer's DiseaseRF1AG058267 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HAINES, JONATHAN L, SAFAR, JIRI G. · 2017 to 2017
$4.0M
Structural correlates of prion strain, phenotype and infectivity in human prion dR01NS083687 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI, SUREWICZ, WITOLD K · 2014 to 2018
$2.9M
CDC HHS CDC 000309CK14Investissements 276 d'avenir ANR-10-IAIHU-06NHMRC Practitioner Fellowship APP1105784NIAID NIH HHS P01 AI106705NIA NIH HHS RF1 AG058267NIH HHS NIH 5R01NS083687NIH HHS NIH P01AI106705NINDS NIH HHS R01 NS083687
6 · The paper itself

Abstract

The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of cadaveric dura mater (DM) grafts.To investigate this phenomenon further, a cohort of 27 iCJD cases - 21 with adequate number of histopathological sections - originating from Australia, France, Italy, and the Unites States, were examined by immunohistochemistry, amyloid staining, and Western blot analysis of the scrapie prion protein (PrP

Indexed as

Amyloid beta-PeptidesAdultAgedAge FactorsAlzheimer DiseaseBrainCerebral Amyloid AngiopathyCohort StudiesCreutzfeldt-Jakob SyndromeEncephalopathy, Bovine SpongiformFemaleHumansIatrogenic DiseaseInternationalityMaleMiddle AgedAmyloid beta-PeptidesMAPT protein, humanPrPSc Proteinstau ProteinsAmyloid-βCerebral amyloid angiopathyiCJDPathologyThioflavin S

Identifiers

PMID29310723
PMCPMC5759292
OpenAlexW2783628071

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.