ArticleParasites & vectors2018
Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Global Prevalence of Anaplasma phagocytophilum in Cattle: A One Health Perspective, Meta-Analysis and Future Predictions (up to 2035).Veterinary medicine and science · 2025Pooled it
- First detection ofFrontiers in veterinary science · 2026Article
- Identification of hemolytic anemia in Korean indigenous cattle with a criteria value of reticulocyte count, indirect bilirubin, and L-lactate concentration.Frontiers in veterinary science · 2024Article
- Host-pathogen associations revealed by genotyping of European strains of Anaplasma phagocytophilum to describe natural endemic cycles.Parasites & vectors · 2023Article
- A One Health Evaluation of the Surveillance Systems on Tick-Borne Diseases in the Netherlands, Spain and Italy.Veterinary sciences · 2022Article
- Prevalence and Genotyping ofAnimals : an open access journal from MDPI · 2022Article
- First report on molecular surveillance based on duplex detection of Anaplasma marginale and Theileria annulata in dairy cattle from Punjab, Pakistan.Tropical animal health and production · 2022Article
- Seasonality and Geography Have a Greater Influence than the Use of Chlorine-Based Cleaning Agents on the Microbiota of Bulk Tank Raw Milk.Applied and environmental microbiology · 2021Article
- Article
- Seroprevalence and Risk Factors ofAnimals : an open access journal from MDPI · 2021Article
- Enlisting thePathogens (Basel, Switzerland) · 2021Article
- Co-infection, reinfection and superinfection with Anaplasma phagocytophilum strains in a cattle herd based on ankA gene and multilocus sequence typing.Parasites & vectors · 2020Article
- Anaplasma phagocytophilum evolves in geographical and biotic niches of vertebrates and ticks.Parasites & vectors · 2019Article
- Co-circulation of different A. phagocytophilum variants within cattle herds and possible reservoir role for cattle.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaplasma phagocytophilum is an obligate intracellular, tick-transmitted bacterium that causes granulocytic anaplasmosis in humans and several mammalian species including domestic ruminants where it is called tick-borne fever (TBF). Different genetic variants exist but their impact with regard to putative differences in host associations and pathogenicity are not yet completely understood.
methodsNatural infections with A. phagocytophilum in a dairy cattle herd in Germany were investigated over one pasture season by using serology, haematology, blood chemistry and polymerase chain reaction (PCR). Sequence analysis of partial 16S rRNA, groEL, msp2 and msp4 genes of A. phagocytophilum was carried out in order to trace possible genetic variants and their relations between cattle, roe deer (Capreolus capreolus) and ticks (Ixodes ricinus) in this area.
resultsIn total 533 samples from 58 cattle, 310 ticks, three roe deer and one wild boar were examined. Our results show (i) typical clinical symptoms of TBF in first-time infected heifers, such as high fever, reduced milk yield, lower limb oedema and typical haematological and biochemical findings such as severe leukopenia, erythropenia, neutropenia, lymphocytopenia, monocytopenia, a significant increase in creatinine and bilirubin and a significant decrease in serum albumin, γ-GT, GLDH, magnesium and calcium; (ii) a high overall prevalence of A. phagocytophilum infections in this herd as 78.9% (15/19) of the naïve heifers were real-time PCR-positive and 75.9% (44/58) of the entire herd seroconverted; and (iii) a high level of sequence variation in the analysed genes with five variants of the 16S rRNA gene, two variants of the groEL gene, three variants of the msp2 gene and four variants in the msp4 gene with certain combinations of these variants.
conclusionsIn cattle particular combinations of the genetic variants of A. phagocytophilum occurred, whereas three roe deer showed different variants altogether. This is indicative for a sympatric circulation of variants in this small geographical region (< 1 km
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