Evidence map›Paper›PMID 29310631›Full record

Trial reportBMC complementary and alternative medicine2018

Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial.

Charoonsri Chusak, Thavaree Thilavech, Christiani Jeyakumar Henry, Sirichai Adisakwattana

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Beneficial Effects ofJournal of obesity · 2026
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  5. Plants (Basel, Switzerland) · 2025
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  6. Dragon Fruit Peel Waste (Antioxidants (Basel, Switzerland) · 2023
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  7. Review
  8. Article
  9. Biology · 2021
    Article
  10. Extraction methods of butterfly pea (Journal of food science and technology · 2021
    Review
  11. Butterfly Pea Flower (Antioxidants (Basel, Switzerland) · 2021
    Article
  12. Article
  13. Anthocyanins FromFrontiers in plant science · 2021
    Review
  14. Article
  15. Review
  16. Butterfly Pea (Frontiers in plant science · 2019
    Review
  17. A Commercial Potential Blue Pea (Evidence-based complementary and alternative medicine : eCAM · 2019
    Article
  18. A clinical study onAvicenna journal of phytomedicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Charoonsri ChusakDepartment of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama 1 Rd., Wangmai, Pathumwan, Bangkok, 10330, Thailand.
Thavaree ThilavechDepartment of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama 1 Rd., Wangmai, Pathumwan, Bangkok, 10330, Thailand.
Christiani Jeyakumar HenryClinical Nutrition Research Centre (CNRC), Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Sirichai AdisakwattanaDepartment of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Rama 1 Rd., Wangmai, Pathumwan, Bangkok, 10330, Thailand. Sirichai.a@chula.ac.th.ORCID http://orcid.org/0000-0002-7938-6561
Chulalongkorn University · THAgency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects of Clitoria ternatea flower extract (CTE) on postprandial plasma glycemia response and antioxidant status in healthy men.

methodsIn a randomized, crossover study, 15 healthy men (ages 22.53 ± 0.30 years; with body mass index of 21.57 ± 0.54 kg/m

resultsAfter 30 min ingestion, the postprandial plasma glucose and insulin levels were suppressed when consuming sucrose plus 1 g and 2 g CTE. In addition, consumption of CTE alone did not alter plasma glucose and insulin concentration in the fasting state. The significant increase in plasma antioxidant capacity (ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC), trolox equivalent antioxidant capacity (TEAC), and protein thiol) and the decrease in malondialdehyde (MDA) level were observed in the subjects who received 1 g and 2 g CTE. Furthermore, consumption of CTE protected sucrose-induced reduction in ORAC and TEAC and increase in plasma MDA.

conclusionsThese findings suggest that an acute ingestion of CTE increases plasma antioxidant capacity without hypoglycemia in the fasting state. It also improves postprandial glucose, insulin and antioxidant status when consumed with sucrose.

trial registrationThai Clinical Trials Registry: TCTR20170609003 . Registered 09 September 2017. 'retrospectively registered'.

Indexed as

AdultAntioxidantsBeveragesBlood GlucoseClitoriaCross-Over StudiesHumansInsulinLipid PeroxidationMalePlant ExtractsPostprandial PeriodYoung AdultAntioxidantsBlood GlucoseInsulinPlant ExtractsAntioxidantClitoria ternateaGlucoseGlycemiaInsulinSucrose

Identifiers

PMID29310631
PMCPMC5759795
OpenAlexW2783802379

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.