ArticleBMC cardiovascular disorders2018
Association of rs662799 in APOA5 with CAD in Chinese Han population.
Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Nomogram developed withCardiovascular diagnosis and therapy · 2024Article
- The pathogenic mutations of APOA5 in Chinese patients with hyperlipidemic acute pancreatitis.Lipids in health and disease · 2024Article
- Apolipoprotein A5 gene polymorphism (rs662799) and cardiovascular disease in end-stage kidney disease patients.BMC nephrology · 2022Article
- Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing.Human genomics · 2022Article
- Genetically-engineered hamster models: applications and perspective in dyslipidemia and atherosclerosis-related cardiovascular disease.Medical review (2021) · 2021Article
- Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation.BMC cardiovascular disorders · 2021Article
- Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.Molecular biology reports · 2020Article
- Influence ofFrontiers in pharmacology · 2018Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCAD (Coronary Artery Disease) is a complex disease that influenced by various environmental and genetic factors. Previous studies have found many single nucleotide polymorphisms (SNPs) associated with the risk of CAD occurrence. However, the results are inconsistent. In this study, we aim to investigate genetic etiology in Chinese Han population by analysis of 7 SNPs in lipid metabolism pathway that previously has been reported to be associated with CAD.
methodsA total of 631 samples were used in this study, including 435 CAD cases and 196 normal healthy controls. SNP genotyping were conducted via multiplex PCR amplifying followed by NGS (next-generation sequencing).
resultsRs662799 in APOA5 (Apolipoprotein A5) gene was associated with CAD in Chinese Han population (Odds-ratio = 1.374, P-value = 0.03). No significant association was observed between the rest of SNPs and CAD. Stratified association analysis revealed rs5882 was associated with CAD in non-hypertension group (Odds-ratio = 1.593, P-value = 0.023). Rs1800588 was associated with CAD in smoking group (Odds-ratio = 1.603, P-value = 0.035).
conclusionThe minor allele of rs662799 was the risk factor of CAD occurrences in Chinese Han population.
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