ArticleXenobiotica; the fate of foreign compounds in biological systems2019
Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.
Article in Xenobiotica; the fate of foreign compounds in biological systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Design, Synthesis, and Biological Studies of Flavone-Based Esters and Acids as Potential P450 2A6 Inhibitors.Chemical research in toxicology · 2023Article
- Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1.Chemical research in toxicology · 2023Article
- Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13.Xenobiotica; the fate of foreign compounds in biological systems · 2022Article
- Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage.International journal of molecular sciences · 2021Review
- Roles of cytochrome P450 2A6 in the oxidation of flavone, 4'-hydroxyflavone, and 4'-, 3'-, and 2'-methoxyflavones by human liver microsomes.Xenobiotica; the fate of foreign compounds in biological systems · 2021Article
- Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2'-, 3'-, 4'- and 6-hydroxyflavanones by human cytochrome P450 enzymes.Xenobiotica; the fate of foreign compounds in biological systems · 2021Article
- Preference forXenobiotica; the fate of foreign compounds in biological systems · 2020Article
- Dibromopinocembrin and Dibromopinostrobin Are Potential Anti-Dengue Leads with Mild Animal Toxicity.Molecules (Basel, Switzerland) · 2020Article
- Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes.Xenobiotica; the fate of foreign compounds in biological systems · 2019Article
- Dietary Flavonoids Interaction with CREB-BDNF Pathway: An Unconventional Approach for Comprehensive Management of Epilepsy.Current neuropharmacology · 2019Review
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
1. We previously reported that flavone and flavanone interact spectrally with cytochrome P450 (P450 or CYP) 2A6 and 2A13 and other human P450s and inhibit catalytic activities of these P450 enzymes. In this study, we studied abilities of CYP1A1, 1A2, 1B1, 2A6, 2A13, 2C9 and 3A4 to oxidize flavone and flavanone. 2. Human P450s oxidized flavone to 6- and 5-hydroxylated flavones, seven uncharacterized mono-hydroxylated flavones, and five di-hydroxylated flavones. CYP2A6 was most active in forming 6-hydroxy- and 5-hydroxyflavones and several mono- and di-hydroxylated products. 3. CYP2A6 was also very active in catalyzing flavanone to form 2'- and 6-hydroxyflavanones, the major products, at turnover rates of 4.8 min
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