ArticleMedicine2017
Severe pertussis infection: A clinicopathological study.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Influencing factors for severe pertussis among Chinese children: A meta-analysis.Human vaccines & immunotherapeutics · 2026Pooled it
- Variability in the Diagnostic Criteria for Severe Pertussis: A Systematic Review.JAMA network open · 2026Pooled it
- Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.Critical care (London, England) · 2025Pooled it
- SEVERE PERTUSSIS IN CHILDHOOD: UPDATE AND CONTROVERSY - SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019Pooled it
- Clinical characteristics and prognosis of exchange transfusion in infants with severe pertussis.BMC pediatrics · 2025Article
- Article
- Hyperleukocytosis associated with pertussis: Two case reports.World journal of clinical cases · 2025Article
- Hydroxyurea for Malignant Pertussis in Critically Ill Children.Critical care explorations · 2025Article
- [Application of exchange transfusion in neonates with severe pertussis and hyperleukocytosis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Association between real-time polymerase chain reaction cycle threshold value and clinical presentation in children with Bordetella pertussis.Italian journal of pediatrics · 2024Article
- Severe Pertussis Infection With Hyperleukocytosis in a 10-Month-Old Unvaccinated Amish Female: A Case Report.Cureus · 2022Article
- Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study.Annals of intensive care · 2021Article
- [Research advances in the treatment strategies for severe pertussis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Review
- Leukoreduction and hydroxyurea in malignant pertussis: A case series.Clinical case reports · 2020Article
- Clinical Profile of Critical Pertussis in Children at a Pediatric Intensive Care Unit in Northern India.Indian pediatrics · 2020Article
- The clinical characteristics and prognosis of pertussis among unvaccinated infants in the pediatric intensive care unit.Turk pediatri arsivi · 2020Article
- Review
- Clinical and epidemiological characteristics of whooping cough in hospitalized patients of a tertiary care hospital in Peru.Revista Brasileira de terapia intensiva · 2019Article
- Histopathology of Bordetella pertussis in the Baboon Model.Infection and immunity · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the clinicopathological features of pertussis in children admitted to a tertiary-care university hospital in Brazil.This was a retrospective cohort study of all pediatric hospital admissions with pertussis from January 1, 2008 to December 31, 2014. We also reported the autopsy findings in children who died.Fifty-five patients admitted to the hospital over the study period had laboratorial confirmation of Bordetella pertussis infection, 17 (30.9%) needed pediatric intensive care unit (PICU) admission and 6 (10.9%) died. All patients who died were younger than 60 days old and unvaccinated for pertussis; 50% of them had coinfection with respiratory syncytial virus. Leukocyte count ≥40,000/mm at hospital admission was an independent risk factor for PICU admission. Mean heart rate during hospitalization ≥160 bpm was an independent risk factor for death. A cut-off point of 41,200 leukocytes/mm at hospital admission had sensitivity of 64.7% and specificity of 89.5% to predict PICU admission (area under the curve 0.75) and sensitivity of 100% and specificity of 81.6% to predict death (area under the curve 0.93). Autopsy showed medial thickening of small pulmonary arteries in 80% of patients who had pulmonary hypertension; intravascular aggregates of leukocytes or pulmonary thrombosis were not observed. Immunohistochemical staining of tissue samples obtained at autopsy identified B pertussis and respiratory syncytial virus in pulmonary and extra-pulmonary sites.Marked leukocytosis at presentation was associated with morbidity and mortality in children hospitalized with pertussis. Implementation of preventive strategies is crucial to diminish the incidence of the disease, especially in young unimmunized infants.
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