Evidence map›Paper›PMID 29309986›Full record

ArticleDifferentiation; research in biological diversity

The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration.

Heather L Mentrup, Amanda Hartman, Elizabeth L Thames, Wassim A Basheer, Lydia E Matesic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Heather L MentrupDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Amanda HartmanDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Elizabeth L ThamesDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Wassim A BasheerDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Lydia E MatesicDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. Electronic address: lmatesic@biol.sc.edu.
University of South Carolina Sumter · US

Funding

TISSUE BIOREPOSITORYP20RR017698 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FAYAD, RAJA · 2002 to 2011
$22.5M
TISSUE BIOREPOSITORY COREP30GM103336 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BERGER, FRANKLIN G. · 2013 to 2017
$5.4M
Intracellular Sorting of Connexin 43 by the Ubiquitin Ligase Wwp1R01HL104030 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MATESIC, LYDIA ELEANOR · 2010 to 2014
$1.7M
NCRR NIH HHS P20 RR017698NHLBI NIH HHS R01 HL104030NIGMS NIH HHS P30 GM103336
6 · The paper itself

Abstract

Maintenance of the intestinal mucosa is driven by local signals that coordinate epithelial proliferation, differentiation, and turnover in order to separate antigenic luminal contents from the host's immune system. Breaches in this barrier promote gastrointestinal pathologies ranging from inflammatory bowel disease to cancer. The ubiquitin ligase ITCH is known to regulate immune responses, and loss of function of ITCH has been associated with gastrointestinal inflammatory disorders, particularly in the colon. However, the small intestine appears to be spared from this pathology. Here we explored the physiological mechanism that underlies the preservation of mucosal homeostasis in the small intestine in mice lacking ITCH (Itch

Indexed as

AnimalsCell DifferentiationCell ProliferationHomeostasisIntestinal MucosaIntestine, SmallMice, Inbred C57BLUbiquitinUbiquitinCell migrationColorectal cancerE3 ubiquitin ligaseEpithelial differentiationIntestinal homeostasisITCH

Identifiers

PMID29309986
PMCPMC5826883
OpenAlexW2771387976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.