Evidence map›Paper›PMID 29309858›Full record

ArticleNeuroscience letters2018

White matter tractography of the neural network for speech-motor control in children who stutter.

Ehsan Misaghi, Zhaoran Zhang, Vincent L Gracco, Luc F De Nil, Deryk S Beal

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Ehsan MisaghiNeuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Institute for Stuttering Treatment and Research, Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
Zhaoran ZhangCollege of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Vincent L GraccoSchool of Communication Sciences and Disorders, McGill University, Montreal, QC, Canada; Haskins Laboratories, New Haven, CN, USA.
Luc F De NilDepartment of Speech-Language Pathology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Deryk S BealDepartment of Speech-Language Pathology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada. Electronic address: dbeal@hollandbloorview.ca.
Holland Bloorview Kids Rehabilitation Hospital · CAMcGill University · CASichuan University · CNUniversity of Alberta · CAUniversity of Toronto · CA

Funding

Neural control and sensorimotor mechanisms in stutteringR01DC007603 · NIDCD · UNIVERSITY OF WASHINGTON · PI MAX, LUDO · 2006 to 2010
$1.9M
The Negative BOLD Response in Speech Production and Persistent StutteringR21DC015855 · NIDCD · HASKINS LABORATORIES, INC. · PI GRACCO, VINCENT L. · 2017 to 2018
$360k
CIHR M0P-68969NIDCD NIH HHS R01 DC007603NIDCD NIH HHS R21 DC015855
6 · The paper itself

Abstract

Stuttering is a neurodevelopmental speech disorder with a phenotype characterized by speech sound repetitions, prolongations and silent blocks during speech production. Developmental stuttering affects 1% of the population and 5% of children. Neuroanatomical abnormalities in the major white matter tracts, including the arcuate fasciculus, corpus callosum, corticospinal, and frontal aslant tracts (FAT), are associated with the disorder in adults who stutter but are less well studied in children who stutter (CWS). We used deterministic tractography to assess the structural connectivity of the neural network for speech production in CWS and controls. CWS had higher fractional anisotropy and axial diffusivity in the right FAT than controls. Our findings support the involvement of the corticostriatal network early in persistent developmental stuttering.

Indexed as

ChildDiffusion Tensor ImagingHumansMaleMotor ActivityNerve NetNeural PathwaysSpeechStutteringWhite MatterDeterministic tractographyDevelopmental stutteringDiffusion tensor imaging (DTI)Magnetic resonance imaging (MRI)Motor controlSpeech production

Identifiers

PMID29309858
PMCPMC5839127
OpenAlexW2782290492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.