ArticleMolecular biology and evolution2018
Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster.BMC microbiology · 2021Pooled it
- Rapid Genomic Adaptation of Drosophila Melanogaster to Wolbachia Elimination.Microbial ecology · 2026Article
- Experimental evolution-induced transcriptome and phenotype responses of Drosophila melanogaster to novel thermal environments.The Journal of experimental biology · 2025Article
- Pervasive sex-dependent effects in the genetic architecture of starvation resistance inScience advances · 2025Article
- Natural variation in phospholipase IPLA2-VIA contributes to starvation sensitivity inbioRxiv : the preprint server for biology · 2025Article
- Selection for Early Reproduction Leads to Accelerated Aging and Extensive Metabolic Remodeling in Drosophila melanogaster.Genome biology and evolution · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila.PLoS genetics · 2024Article
- Gene expression variation underlying tissue-specific responses to copper stress inbioRxiv : the preprint server for biology · 2023Article
- Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity.bioRxiv : the preprint server for biology · 2023Article
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Natural alleles at theProceedings. Biological sciences · 2022Article
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Pupal size as a proxy for fat content in laboratory-reared and field-collected Drosophila species.Scientific reports · 2022Article
- Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory EvolvedInternational journal of molecular sciences · 2022Article
- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster.Molecular biology and evolution · 2021Article
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.G3 (Bethesda, Md.) · 2021Article
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Experimental evolution affords the opportunity to investigate adaptation to stressful environments. Studies combining experimental evolution with whole-genome resequencing have provided insight into the dynamics of adaptation and a new tool to uncover genes associated with polygenic traits. Here, we selected for starvation resistance in populations of Drosophila melanogaster for over 80 generations. In response, the starvation-selected lines developed an obese condition, storing nearly twice the level of total lipids than their unselected controls. Although these fats provide a ∼3-fold increase in starvation resistance, the imbalance in lipid homeostasis incurs evolutionary cost. Some of these tradeoffs resemble obesity-associated pathologies in mammals including metabolic depression, low activity levels, dilated cardiomyopathy, and disrupted sleeping patterns. To determine the genetic basis of these traits, we resequenced genomic DNA from the selected lines and their controls. We found 1,046,373 polymorphic sites, many of which diverged between selection treatments. In addition, we found a wide range of genetic heterogeneity between the replicates of the selected lines, suggesting multiple mechanisms of adaptation. Genome-wide heterozygosity was low in the selected populations, with many large blocks of SNPs nearing fixation. We found candidate loci under selection by using an algorithm to control for the effects of genetic drift. These loci were mapped to a set of 382 genes, which associated with many processes including nutrient response, catabolic metabolism, and lipid droplet function. The results of our study speak to the evolutionary origins of obesity and provide new targets to understand the polygenic nature of obesity in a unique model system.
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