Evidence map›Paper›PMID 29309603›Full record

ArticleThe Journal of infectious diseases2018

A Nonhuman Primate Model for Rectally Transmitted Syphilis.

Cassandra Tansey, Chunxia Zhao, Andre Hopkins, Jana M Ritter, Yetunde F Fakile, Allan Pillay, Samantha S Katz, Lara Pereira, James Mitchell, Frank Deyounks and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Cassandra TanseyDivision of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia.
Chunxia ZhaoLibra Management Group, Atlanta, Georgia.
Andre HopkinsDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jana M RitterDivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.
Yetunde F FakileDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Allan PillayDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Samantha S KatzDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Lara PereiraDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
James MitchellDivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.
Frank DeyounksLibra Management Group, Atlanta, Georgia.
Ellen N KershDivision of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Janet M McNichollDivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.
Sundaram Ajay VishwanathanDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Centers for Disease Control and Prevention · USAlibaba Group (United States) · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Among men who have sex with men (MSM), those with a diagnosis of syphilis or other rectal sexually transmitted infections (STIs) are at a higher risk for human immunodeficiency virus acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first nonhuman primate model for rectally transmitted syphilis by exposing simian/human immunodeficiency virus-infected and naive rhesus macaques to Treponema pallidum in the rectum. All animals showed mucosal lesions, systemic dissemination, and seroconversion (treponemal antibodies). This model would be valuable for studying the manifestations of and interventions for T. pallidum infection, with and without human immunodeficiency virus coinfection.

Indexed as

Macaca mulattaAnimalsCD4-Positive T-LymphocytesCoinfectionDisease Models, AnimalFemaleMalePeptides, CyclicRectumSexually Transmitted DiseasesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSyphilisTreponema pallidumViremiabactenecinPeptides, Cyclic

Identifiers

PMID29309603
PMCPMC5939619
OpenAlexW2780894850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.