ArticleAmerican journal of epidemiology2018
Multimorbidity, Mortality, and Long-Term Physical Functioning in 3 Prospective Cohorts of Community-Dwelling Adults.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multimorbidity of non-communicable diseases in low-income and middle-income countries: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Patterns of multimorbidity and some psychiatric disorders: A systematic review of the literature.Frontiers in psychology · 2022Pooled it
- Pooled it
- Pooled it
- The association between HIV infection, disability and lifestyle activity among middle-aged and older adults: an analytical cross-sectional study in Ivory Coast (the VIRAGE study).BMC public health · 2024Trial
- Eight-Year Changes in Multimorbidity and Frailty in Adults With Type 2 Diabetes Mellitus: Associations With Cognitive and Physical Function and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Evaluating the Test-Retest Reliability and Measurement Error of a Sit-Stand-Power Test in Individuals Treated for Cancer.Integrative cancer therapiesTrial
- Validating ICD code case definitions for condition case ascertainment in multimorbidity measurement: a retrospective chart review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The association between multimorbidity and arteriovenous fistula creation outcomes.Journal of vascular surgery · 2026Article
- Comorbidities and lifestyle changes as predictors of the multiple sclerosis prodrome: A prospective cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Association of multimorbidity with mortality risk in Chinese senior adults: a population-based cohort study.BMC geriatrics · 2026Article
- Development of a risk assessment model for multimorbidity of diabetes, hypertension, and coronary heart disease with XGBoost in primary care in Shanghai, China: a retrospective study.BMC cardiovascular disorders · 2026Article
- Association between health literacy and chronic diseases in Anhui Province: findings from a province-wide cross-sectional survey of 16,067 individuals.Scientific reports · 2025Article
- Article
- Prevalence, incidence, risk factors and economic burden in multimorbidity among adult Indians: the MILAN cohort study protocol.BMJ open · 2025Article
- Longitudinal Trajectories of Multimorbidity and Psychosocial Resilience Resources in Midlife and Older Adults: Findings From the Health and Retirement Study.Journal of aging and health · 2025Article
- Capturing the care of complex community-based health center patients: A comparison of multimorbidity indices and clinical classification software.Health services research · 2025Article
- Article
- Epidemiology of Respiratory Syncytial Virus in Adults and Children With Medically Attended Acute Respiratory Illness Over Three Seasons.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Age-specific Multimorbidity Patterns and Burden on All-Cause Mortality and Public Direct Medical Expenditure: A Retrospective Cohort Study.Journal of epidemiology and global health · 2024Observational
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Multimorbidity is prevalent, but its optimal quantification and associations with mortality rate and physical functioning in young through older adults are uncertain. We used data collected using the Short Form-36 in the Nurses' Health Study (enrollment started in 1976), Nurses' Health Study II (begun in 1989), and Health Professionals Follow-up Study (begun in 1986) to identify associations of a multimorbidity-weighted index (MWI) and common alternative indices with mortality and future physical functioning. We used Cox proportional hazard ratios to determine incident 10-year mortality and general linear models to obtain coefficients for the associations of MWI with 4- and 8-year physical functioning. At baseline, mean values for the 219,950 participants were 55.0 (standard deviation, 3.7) years for age; 3.8 (range, 0-51) for MWI; 2.7 (range, 0-23) for disease count, and 0.43 (range, 0-13) for Charlson Comorbidity Index (CCI). During follow-up, 23,709 deaths (10.8%) occurred. CCI, MWI, and disease count were 0 for 77%, 12%, and 19% of participants, respectively. When comparing persons in the highest quartiles with those in the lowest, the hazard ratios for mortality were 6.04 (95% confidence interval (CI): 6.00, 6.09; P for trend < 0.0001) for the MWI, 4.86 (95% CI: 4.81, 4.91; P for trend < 0.0001) for disease count, and 3.29 (95% CI: 3.26, 3.32; P for trend < 0.0001) for the CCI. For future physical functioning, MWI had the best model fit and explained the greatest variance. Multimorbidity has important associations with future physical functioning and mortality that are easily captured with a readily measured index.
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