ArticlePloS one2018
Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- UV-cure hydrogels for cardiac regeneration: a comprehensive review.Stem cell research & therapy · 2025Review
- Switchable DNA Photocatalysts for Radical Polymerization Controlled by Chemical Stimuli.Journal of the American Chemical Society · 2023Article
- Versatile Supramolecular Complex for Targeted Antimicrobial Photodynamic Inactivation.Bioconjugate chemistry · 2022Article
- 3D bioprinting and photocrosslinking: emerging strategies & future perspectives.Biomaterials advances · 2022Review
- Development of alginate and gelatin-based pleural and tracheal sealants.Acta biomaterialia · 2021Article
- Increased yield of gelatin coated therapeutic cells through cholesterol insertion.Journal of biomedical materials research. Part A · 2021Article
- Cell Death Persists in Rapid Extrusion of Lysis-Resistant Coated Cardiac Myoblasts.Bioprinting (Amsterdam, Netherlands) · 2020Article
- Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo-crosslinkable hydrogel bioscaffolds.Stem cells translational medicine · 2020Review
- Coatings on mammalian cells: interfacing cells with their environment.Journal of biological engineering · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation technologies. While eosin is used in conjunction with tertiary amines as a water-soluble photoinitiation system, eosin is not widely sold as a conjugate with antibodies and other targeting biomolecules. Here we evaluate the utility of fluorescein-labeled bioconjugates to photopolymerize targeted coatings on live cells. We show that although fluorescein conjugates absorb approximately 50% less light energy than eosin in matched photopolymerization experiments using a 530 nm LED lamp, appreciable polymer thicknesses can still be formed in cell compatible environments with fluorescein photosensitization. At low photoinitiator density, eosin allows more sensitive initiation of gelation. However at higher functionalization densities, the thickness of fluorescein polymer films begins to rival that of eosin. Commercial fluorescein-conjugated antibodies are also capable of generating conformal, protective coatings on mammalian cells with similar viability and encapsulation efficiency as eosin systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.