ArticlePloS one2018
Enhancement of lateral flow assay performance by electromagnetic relocation of reporter particles.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The evolution of next-generation lateral flow assays for bacterial and fungal diagnostics.Mikrochimica acta · 2026Review
- Next-generation hybrid bioanalytical platforms and clinical integration of TDM technologies for precision monitoring to optimize last-resort antibiotic therapy.Frontiers in pharmacology · 2026Review
- Evaluation of lateral flow devices for rabies diagnosis in decomposed animal brain samples.Tropical medicine and health · 2025Article
- Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics.Advances in biochemical engineering/biotechnology · 2022Review
- Antibody- and nucleic acid-based lateral flow immunoassay for Listeria monocytogenes detection.Analytical and bioanalytical chemistry · 2021Review
- Comparison of Single- and Mixed-Sized Gold Nanoparticles on Lateral Flow Assay for Albumin Detection.Biosensors · 2021Article
- Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis.Theranostics · 2021Review
- Improvement in Detection Limit for Lateral Flow Assay of Biomacromolecules by Test-Zone Pre-enrichment.Scientific reports · 2020Article
- Magnetic Lateral Flow Immunoassays.Diagnostics (Basel, Switzerland) · 2020Review
- PCB-Based Magnetometer as a Platform for Quantification of Lateral-Flow Assays.Sensors (Basel, Switzerland) · 2019Article
- Visual aptamer-based capillary assay for ethanolamine using magnetic particles and strand displacement.Mikrochimica acta · 2019Article
- Article
- Machine Learning Approach to Enhance the Performance of MNP-Labeled Lateral Flow Immunoassay.Nano-micro letters · 2019Article
- Correction: Enhancement of lateral flow assay performance by electromagnetic relocation of reporter particles.PloS one · 2019Article
- Development of a highly sensitive magneto-enzyme lateral flow immunoassay for dengue NS1 detection.PeerJ · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Lateral flow assays (LFAs) are a widely-used point-of care diagnostic format, but suffer from limited analytical sensitivity, especially when read by eye. It has recently been reported that LFA performance can be improved by using magnetic reporter particles and an external magnetic field applied at the test line. The mechanism of sensitivity/performance enhancement was suggested to be concentration/retardation of reporter particles at the test line. Here we demonstrate an additional mechanism of particle relocation where reporter particles from the lower depths of the translucent LFA strip relocate to more-visible locations nearer to the top surface, producing a more visible signal. With a magnetic field we observed an improvement in sensitivity of human chorionic gonadotropin (hCG) detection from 1.25 ng/mL to 0.31 ng/mL. We also observed an increase of the color intensity per particle in test lines when the magnetic field was present.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.