ArticleNature biotechnology2018
Functional interrogation and mining of natively paired human V
Abstract read
In one paragraph
Article in Nature biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence in endoscopy and colonoscopy: a comprehensive bibliometric analysis of global research trends.Frontiers in medicine · 2025Pooled it
- Trial
- Anti-malaria antibody engineering broadens recognition motifs and reveals new homotypic interactions that enhance protective breadth.Nature communications · 2026Article
- Integrating fab phage and yeast display through seamless transfer of paired heavy- and light-chain libraries for efficient antibody discovery.Antibody therapeutics · 2026Article
- The evolution of display technologies for antibody drug discovery.Trends in biotechnology · 2026Review
- The adaptive immune receptors in a big data world.ImmunoHorizons · 2026Review
- Potent Monoclonal Antibodies Against Circulating Yellow Fever Virus Strains from Donors Immunized with the 17D Vaccine.The American journal of tropical medicine and hygiene · 2026Article
- Engineered neutrophil engagers overcome IgA limitations and reprogram resting neutrophils for cancer immunotherapy.Journal of biological engineering · 2025Article
- Article
- Anti-Malaria Antibody Engineering Broadens Recognition Motifs and Reveals New Homotypic Interactions that Enhance Protective Breadth.bioRxiv : the preprint server for biology · 2025Article
- Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.Communications biology · 2025Article
- Isolation of a Monoclonal Human scFv Against Cytomegalovirus pp71 Antigen Using Yeast Display.Antibodies (Basel, Switzerland) · 2025Article
- Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiae.Nature communications · 2025Article
- Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells.Nature biotechnology · 2025Article
- Optimized single-cell gates for yeast display screening.Protein engineering, design & selection : PEDS · 2025Article
- Beyond Single Clones: High-Throughput Sequencing in Antibody Discovery.Cold Spring Harbor protocols · 2025Article
- Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome.Frontiers in immunology · 2025Article
- High-throughput specificity profiling of antibody libraries using ribosome display and microfluidics.Cell reports methods · 2024Article
- Backstage Heroes-Yeast in COVID-19 Research.International journal of molecular sciences · 2024Review
- Human monoclonal antibody cloning and expression with overlap extension PCR and short DNA fragments.Journal of immunological methods · 2024Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Bo WangDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Brandon J DeKoskyVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Morgan R TimmVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Jiwon LeeDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Erica NormandinVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
John MisasiVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Rui KongVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Jonathan R McDanielDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
George DelidakisDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-4330-9476
Kendra E LeighVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.ORCID 0000-0002-6467-3330
Thomas NiezoldVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Chang W ChoiVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Elise G VioxVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Ahmed FahadDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA.
Alberto CagigiVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Aurélie PloquinVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Kwanyee LeungVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Eun Sung YangVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Wing-Pui KongVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
William N VossDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Aaron G SchmidtLaboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
M Anthony MoodyDuke Human Vaccine Institute, Duke University Medical School, Durham, North Carolina, USA.
David R AmbrozakVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Amy R HenryVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Farida LabouneVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Julie E LedgerwoodVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Barney S GrahamVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Mark ConnorsNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Daniel C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Nancy J SullivanVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Andrew D EllingtonCenter for Systems and Synthetic Biology, The University of Texas at Austin, Austin, Texas, USA.
John R MascolaVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
George GeorgiouDepartment of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Funding
HIV Vaccine StudiesZIAAI005035 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DROPULIC, LESIA K · 2009 to 2025
$89.4MThe Genome Analysis CoreZICAI005133 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2019 to 2025
$16.9MMechanisms of Effective Humoral Immune Responses to HIV-1ZIAAI001090 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CONNORS, MARK · 2009 to 2025
$14.8MT Cell Immune Responses To HIV And Other PathogensZIAAI005033 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2009 to 2025
$11.4MComprehensive analysis of human adaptive immune receptors to elucidate correlates of Epstein-Barr virus disease suppressionDP5OD023118 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI DEKOSKY, BRANDON JAMES · 2016 to 2022
$2.2MMechanisms of Norovirus Protective ImmunityR56AI106006 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2014 to 2014
$760kHigh throughput single cell transcriptome analysisR21CA191239 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI ELLINGTON, ANDREW D · 2015 to 2016
$395kNCI NIH HHS R21 CA191239NIAID NIH HHS R56 AI106006NIH HHS DP5 OD023118
Abstract
We present a technology to screen millions of B cells for natively paired human antibody repertoires. Libraries of natively paired, variable region heavy and light (V
Indexed as
Amino Acid SequenceAntibodies, MonoclonalAntibodies, NeutralizingB-LymphocytesHigh-Throughput Nucleotide SequencingHIV-1HIV AntibodiesHIV InfectionsHumansPeptide LibraryAntibodies, MonoclonalAntibodies, NeutralizingHIV AntibodiesPeptide Library
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.