Evidence map›Paper›PMID 29308883›Full record

ArticleBiochemistry2018

Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.

Chuanwu Xia, Freeborn Rwere, Sangchoul Im, Anna L Shen, Lucy Waskell, Jung-Ja P Kim

Abstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chuanwu XiaMedical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.
Freeborn RwereUniversity of Michigan Medical School , Ann Arbor, Michigan 48105, United States.
Sangchoul ImUniversity of Michigan Medical School , Ann Arbor, Michigan 48105, United States.
Anna L ShenMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
Lucy WaskellUniversity of Michigan Medical School , Ann Arbor, Michigan 48105, United States.
Jung-Ja P KimMedical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.

Funding

TRANSGENIC MODELS OF DIOXIN CARCINOGENICITY AND AH RECEPTOR FUNCTIONP01CA022484 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BRADFIELD, CHRISTOPHER A · 1985 to 2011
$9.2M
PARTICIPATION OF CYTOCHROME B5 IN ANESTHETIC METABOLISMR01GM035533 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WASKELL, LUCY A · 1985 to 2010
$2.7M
Microsomal Cytochromes P450 and their Interactions with their Redox PartnersR01GM094209 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WASKELL, LUCY A · 2011 to 2014
$1.5M
Regulation of P450 Activity by Cytochrome P450 OxidoreductaseR01GM097031 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI KIM, JUNG JA P. · 2013 to 2016
$1.2M
NCI NIH HHS P01 CA022484NIGMS NIH HHS R01 GM035533NIGMS NIH HHS R01 GM094209NIGMS NIH HHS R01 GM097031
6 · The paper itself

Abstract

Conformational changes in NADPH-cytochrome P450 oxidoreductase (CYPOR) associated with electron transfer from NADPH to electron acceptors via FAD and FMN have been investigated via structural studies of the four-electron-reduced NADP

Indexed as

Adenosine MonophosphateAmino Acid SubstitutionAnimalsCrystallography, X-RayElectron TransportFlavin-Adenine DinucleotideFlavin MononucleotideKineticsModels, MolecularNADPNADPH-Ferrihemoprotein ReductaseOxidation-ReductionPoint MutationProtein BindingProtein ConformationRatsAdenosine MonophosphateFlavin-Adenine DinucleotideFlavin MononucleotideNADPNADPH-Ferrihemoprotein Reductase

Identifiers

PMID29308883
PMCPMC5967631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.