Evidence map›Paper›PMID 29308613›Full record

ArticleCell journal2018

Effect of Transplantation of Bone Marrow Stromal Cell- Conditioned Medium on Ovarian Function, Morphology and Cell Death in Cyclophosphamide-Treated Rats.

Nasrin Khanmohammadi, Hamid Reza Sameni, Moslem Mohammadi, Abbas Pakdel, Majid Mirmohammadkhani, Houman Parsaie, Sam Zarbakhsh

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cell journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nasrin KhanmohammadiResearch Center of Nervous System Stem Cells, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Hamid Reza SameniResearch Center of Nervous System Stem Cells, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Moslem MohammadiMolecular and Cell Biology Research Center, Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abbas PakdelResearch Center of Nervous System Stem Cells, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Majid MirmohammadkhaniResearch Center for Social Determinants of Health Community Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Houman ParsaieResearch Center of Nervous System Stem Cells, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Sam ZarbakhshResearch Center of Nervous System Stem Cells, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: smzarbakhsh@gmail.com.
Semnan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAlthough stem cell transplantation has beneficial effects on tissue regeneration, but there are still problems such as high cost and safety issues. Since stem cell therapy is largely dependent on paracrine activity, in this study, utilization of transplantation of bone marrow stromal cells (BMSCs)-secretome instead of the cells, into damaged ovaries was evaluated to overcome the limitations of stem cell transplantation. MATERIALS AND

methodsIn this experimental study, BMSCs were cultured and 25-fold concentrated conditioned medium (CM) from BMSCs was prepared. Female rats were injected intraperitoneally with cyclophosphamide (CTX) for 14 days. Then, BMSCs and CM were individually transplanted into bilateral ovaries, and the ovaries were excised after four weeks of treatment. The follicle count was performed using hematoxylin and eosin (H and E) staining and the apoptotic cells were counted using TUNEL assay. Ovarian function was evaluated by monitoring the ability of ovulation and the levels of serum estradiol (E

resultsEvaluation of the ovarian function and structure showed that results of secretome transplantation were almost similar to those of BMSCs transplantation and there was no significant differences between them.

conclusionsBMSCs-secretome is likely responsible for the therapeutic paracrine effect of BMSCs. Stem cellsecretome is expected to overcome the limitations of stem cell transplantation and become the basis of a novel therapy for ovarian damage.

Indexed as

Bone Marrow Stromal CellsChemotherapyConditioned MediumOvaryTransplantation

Identifiers

PMID29308613
PMCPMC5759671
OpenAlexW2896986972

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.