Trial reportDiabetologia2018
Haemoglobin glycation index and risk for diabetes-related complications in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.
Trial report in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Association Between Hemoglobin Glycation Index and Risk of Cardiovascular Disease and All Cause Mortality in Type 2 Diabetic Patients: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE.BMJ open diabetes research & care · 2021Trial
- Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes.The Journal of clinical endocrinology and metabolism · 2020Trial
- Hemoglobin glycation index and renal progression in patients with type 2 diabetes: a 5-year cohort study.Endocrine · 2026Article
- Association Between Hemoglobin Glycation Index and Mortality in Critically Ill Patients With Atrial Fibrillation: A Retrospective Cohort Study.Clinical cardiology · 2026Article
- Sex-specific in the nonlinear associations of hemoglobin glycation index and all-cause mortality in the general US adult population: results from NHANES 1999-2018.Nutrition & metabolism · 2026Article
- Residual glucose metabolism and Long-Term clinical outcomes in multivessel coronary artery disease: A cohort study.Endocrine · 2026Article
- Hemoglobin glycation index and mortality risk in severe community-acquired pneumonia: a retrospective study.Journal of thoracic disease · 2026Article
- Preoperative hemoglobin glycation index and postoperative complications after non-cardiac surgery: a retrospective cohort study.Anesthesiology and perioperative science · 2026Article
- Associations of Hemoglobin Glycation Index with Glucose Variability and Time in Ranges in Patients with Type 2 Diabetes Undergoing Continuous Glucose Monitoring.International journal of medical sciences · 2026Article
- Association of hemoglobin glycation index with the severity and mortality of cardiovascular-kidney-metabolic syndrome: a population-based cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Association between hemoglobin glycation index and poor prognosis in patients with AKI: a retrospective cohort analysis of the MIMIC-IV database.Renal failure · 2025Article
- Hemoglobin glycation index can be used as a predictor of diabetes mellitus and prediabetes: a cohort study.BMC endocrine disorders · 2025Article
- Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score-Matched Study.Orthopaedic surgery · 2025Article
- The relationship between hemoglobin glycation index and the risk of cardiovascular disease in populations with diabetes or prediabetes: a population-based cohort study.Diabetology & metabolic syndrome · 2025Article
- Relationship between hemoglobin glycation index and myocardial mechano-energetic efficiency in non-diabetic individual.Cardiovascular diabetology · 2025Article
- Association between the haemoglobin glycation index and 30-day and 365-day mortality in patients with heart failure admitted to the intensive care unit.Diabetology & metabolic syndrome · 2025Article
- Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association.Scientific reports · 2025Article
- Hemoglobin glycation index and all-cause mortality in adults: insights from a decade-long prospective cohort study.Frontiers in endocrinology · 2025Article
- Association between Hemoglobin Glycation Index and In-Hospital all-cause mortality of patients with Congestive Heart Failure: a retrospective study utilizing the MIMIC-IV database.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 7 countries.
Funding
Abstract
aims/hypothesisPrevious studies have suggested that the haemoglobin glycation index (HGI) can be used as a predictor of diabetes-related complications in individuals with type 1 and type 2 diabetes. We investigated whether HGI was a predictor of adverse outcomes of intensive glucose lowering and of diabetes-related complications in general, using data from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.
methodsWe studied participants in the ADVANCE trial with data available for baseline HbA
resultsIntensive glucose control lowered mortality risk in individuals with high HGI only (HR 0.74 [95% CI 0.61, 0.91]; p = 0.003), while there was no difference in the effect of intensive treatment on mortality in those with high HbA CONCLUSIONS/
interpretationHGI predicts risk for complications in ADVANCE participants, irrespective of treatment allocation, but no better than HbA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.