ArticleCurrent opinion in systems biology2018
Robustness, Accuracy, and Cell State Heterogeneity in Biological Systems.
Article in Current opinion in systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Chronic Stress Segregates Mice into Distinct Behavioral Phenotypes Based on Glucocorticoid Sensitivity.International journal of molecular sciences · 2025Article
- A Bayesian framework for systems model refinement and selection of calcium signaling.Biophysical journal · 2025Article
- Cis-regulatory control of transcriptional timing and noise in response to estrogen.Cell genomics · 2024Article
- Article
- The ability to sense the environment is heterogeneously distributed in cell populations.eLife · 2024Article
- Temporal signals drive the emergence of multicellular information networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Finding new edges: systems approaches to MTOR signaling.Biochemical Society transactions · 2021Review
- Inferring the structures of signaling motifs from paired dynamic traces of single cells.PLoS computational biology · 2021Article
- Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling.Molecular systems biology · 2019Article
- High-Throughput Automated Single-Cell Imaging Analysis Reveals Dynamics of Glioblastoma Stem Cell Population During State Transition.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- Negative feedback increases information transmission, enabling bacteria to discriminate sublethal antibiotic concentrations.Science advances · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The robustness of biological systems is often depicted as a key system-level emergent property that allows uniform phenotypes in fluctuating environments. Yet, analysis of single-cell signaling responses identified multiple examples of cellular responses with high degrees of heterogeneity. Here we discuss the implications of the observed lack of response accuracy in the context of new observations coming from single-cell approaches. Single-cell approaches provide a new way to measure the abundance of thousands of molecular species in a single-cell. Repeatedly, analysis of cell distributions identifies clusters within these distributions where cells can be grouped into specific cell states. If cells in a population occupy distinct cell states, the observed variable response could in fact be accurate for each cell conditioned on its own internal state. In this view, the observed lack of accuracy, i.e. response heterogeneity, could in fact be beneficial and a potentially regulated feature of cell state variability. Therefore, to truly determine whether the observed response heterogeneity is a desired property or a physical limitation, future analysis of signaling heterogeneity must take into account the internal states of cells in the population.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.