ArticleOpen forum infectious diseases2018
The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Oral manifestations in chikungunya patients: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Early Immune Hypoactivation and Persistent Innate Reprogramming Characterize Chronic Chikungunya Disease.bioRxiv : the preprint server for biology · 2026Article
- Research advances in chikungunya virus: Epidemiology, pathogenesis, and control.One health (Amsterdam, Netherlands) · 2026Review
- Predictors of chronic arthralgia following chikungunya virus infection.GMS hygiene and infection control · 2026Article
- First Phosphonic-Type Inhibitors and Activity-Based Probes Specific to the O'nyong-nyong Virus Capsid Protease.ChemMedChem · 2025Article
- Article
- Sedentary behavior, increasing age, and overweight/obesity increase the presence and intensity of the chronic joint pain in individuals affected by Chikungunya fever.Clinical rheumatology · 2024Article
- Vaccine value profile for Chikungunya.Vaccine · 2024Article
- Long chikungunya? An overview to immunopathology of persistent arthralgia.World journal of virology · 2024Review
- Adaptive coping strategies among individuals living with long-term chikungunya disease: a qualitative study in Curaçao.BMJ open · 2024Article
- "It's very saddening, you keep on wondering when the symptoms will be over": A qualitative study exploring the long-term chikungunya disease impact on daily life and well-being, 6 years after disease onset.PLoS neglected tropical diseases · 2023Article
- Factors Associated with Chikungunya Infection among Pregnant Women in Grenada, West Indies.The American journal of tropical medicine and hygiene · 2023Article
- Chikungunya fever.Nature reviews. Disease primers · 2023Review
- Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort.PLoS neglected tropical diseases · 2023Article
- The clinical manifestation and the influence of age and comorbidities on long-term chikungunya disease and health-related quality of life: a 60-month prospective cohort study in Curaçao.BMC infectious diseases · 2022Article
- Long-term Chikungunya sequelae and quality of life 2.5 years post-acute disease in a prospective cohort in Curaçao.PLoS neglected tropical diseases · 2022Article
- Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study.BJOG : an international journal of obstetrics and gynaecology · 2021Observational
- Ferritin, Erythrocyte Sedimentation Rate, and C-Reactive Protein Level in Patients with Chikungunya-Induced Chronic Polyarthritis.The American journal of tropical medicine and hygiene · 2020Observational
- Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age.PLoS neglected tropical diseases · 2020Article
- A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChikungunya virus (CHIKV) is a re-emerging arboviral pathogen. In 2014, an explosive CHIKV outbreak occurred in Grenada, West Indies, infecting approximately 60% of the population. In approximately 50% of cases, CHIKV infection transitions to painful arthralgia that can persist for years. Elucidation of the risk factors for chronic disease is imperative to the development of effective risk management strategies and specific therapeutics.
methodsWe conducted a cross-sectional study of 240 people who were tested for CHIKV during the outbreak. We administered questionnaires to examine demographic, behavioral, psychological, social, and environmental factors to identify associations with chronic disease. Physical examinations were performed and persistent symptoms were recorded.
resultsEthnicity and socioeconomic status were not associated with risk of chronic joint pain. Female sex increased risk, and age was demonstrated to be predictive of chronic CHIKV sequelae. Mosquito avoidance behaviors did not reduce risk. Patients suffering joint pains, generalized body ache, and weakness in the extremities during acute infection were more likely to develop chronic arthralgia, and an increased duration of acute disease also increased risk.
conclusionsThese data demonstrate that chronic CHIKV affects people across the ethnic and socioeconomic spectrum, and it is not reduced by vector avoidance activity. Increased duration of acute symptoms, in particular acute joint pain, was strongly correlated with the risk of persistent arthralgia, thus effective clinical management of acute CHIKV disease could reduce burden of chronic CHIKV.
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