Evidence map›Paper›PMID 29308405›Full record

ArticleOpen forum infectious diseases2017

AIDS-Defining Illnesses at Initial Diagnosis of HIV in a Large Guatemalan Cohort.

Samuel W Reinhardt, Andrej Spec, Johanna Meléndez, Andrea Alonzo Cordon, Ian Ross, William G Powderly, Carlos Mejia Villatoro

Open access · goldAbstract read
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Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Samuel W ReinhardtDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Andrej SpecDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri.
Johanna MeléndezInfectious Diseases Clinic, Department of Internal Medicine, Roosevelt Hospital, Guatemala City, Guatemala.
Andrea Alonzo CordonInfectious Diseases Clinic, Department of Internal Medicine, Roosevelt Hospital, Guatemala City, Guatemala.
Ian RossDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
William G PowderlyDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri.
Carlos Mejia VillatoroInfectious Diseases Clinic, Department of Internal Medicine, Roosevelt Hospital, Guatemala City, Guatemala.
Washington University in St. Louis · USRoosevelt Hospital · GT

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
NCATS NIH HHS KL2 TR002346NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345
6 · The paper itself

Abstract

backgroundAnecdotal evidence suggests that a high proportion of patients diagnosed with HIV in Guatemala present with AIDS. There remain limited data on the epidemiology of AIDS-defining illnesses (ADIs) in Central America.

methodsWe conducted a retrospective cohort study of all patients living with HIV at the largest HIV clinic in Guatemala. Charts were analyzed for clinical and demographic data. Presence of an ADI was assessed by US Centers for Disease Control definitions; patients who presented with an ADI were compared with those without ADI using descriptive statistics.

resultsOf 3686 patients living with HIV, 931 (25.3%) had an ADI at HIV diagnosis, 748 (80.3%) of whom had CD4 counts lower than 200 cells/mm

conclusionsIn this large Guatemalan cohort of patients currently living with HIV, a significant portion presented with an ADI. These data inform the most common ADIs diagnosed among survivors, show that histoplasmosis is more commonly diagnosed in rural patients, and suggest that HIV wasting syndrome may reflect missed histoplasmosis diagnoses.

Indexed as

AIDSAIDS-defining illnessesglobal healthGuatemalaHIV

Identifiers

PMID29308405
PMCPMC5751076
OpenAlexW2559264981

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.