Evidence map›Paper›PMID 29308401›Full record

ArticleOpen forum infectious diseases2017

Comparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009-2015.

Dominic E Dwyer, Ruth Lynfield, Marcelo H Losso, Richard T Davey, Alessandro Cozzi-Lepri, Deborah Wentworth, Timothy M Uyeki, Fred Gordin, Brian Angus, Tavs Qvist and 4 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Dominic E DwyerInstitute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, Sydney, Australia.
Ruth LynfieldMinnesota Department of Health, St. Paul, Minnesota.
Marcelo H LossoHospital J.M. Ramos Mejía, Buenos Aires, Argentina.
Richard T DaveyNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Washington, DC.
Alessandro Cozzi-LepriUniversity College London, London, UK.
Deborah WentworthDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Timothy M UyekiInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia.
Fred GordinVeterans Affairs Medical Center, Washington, DC.
Brian AngusNuffield Department of Medicine, University of Oxford, Oxford, UK.
Tavs QvistDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Sean EmeryKirby Institute, University of New South Wales, Sydney, Australia.
Jens LundgrenDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
James D NeatonDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
INSIGHT Influenza Study Group
Rigshospitalet · DKUniversity of Minnesota · USNational Institutes of Health · USCenters for Disease Control and Prevention · USHospital Ramos Mejía · ARUniversity of Oxford · GBWestmead Hospital · AUUniversity College London · GBUNSW Sydney · AUVeterans Health Administration · USMinnesota Department of Health · US

Funding

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)U01AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2006 to 2010
$120.1M
Influenza and Emerging Infectious DiseasesZIAAI000984 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DAVEY, RICHARD · 2009 to 2025
$44.1M
CCR NIH HHS HHSN261200800001CMedical Research Council MC_UU_12023/22NCI NIH HHS HHSN261200800001ENIAID NIH HHS U01 AI068641
6 · The paper itself

Abstract

backgroundOutcome data from prospective follow-up studies comparing infections with different influenza virus types/subtypes are limited.

methodsDemographic, clinical characteristics and follow-up outcomes for adults with laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2), or B virus infections were compared in 2 prospective cohorts enrolled globally from 2009 through 2015. Logistic regression was used to compare outcomes among influenza virus type/subtypes.

resultsOf 3952 outpatients, 1290 (32.6%) had A(H1N1)pdm09 virus infection, 1857 (47.0%) had A(H3N2), and 805 (20.4%) had influenza B. Of 1398 inpatients, 641 (45.8%) had A(H1N1)pdm09, 532 (38.1%) had A(H3N2), and 225 (16.1%) had influenza B. Outpatients with A(H1N1)pdm09 were younger with fewer comorbidities and were more likely to be hospitalized during the 14-day follow-up (3.3%) than influenza B (2.2%) or A(H3N2) (0.7%;

conclusionsOutpatients infected with influenza A(H1N1)pdm09 or influenza B were more likely to be hospitalized than those with A(H3N2). Hospitalized patients infected with A(H1N1)pdm09 were younger and more likely to have severe disease at study entry (measured by ICU enrollment), but did not have worse 60-day outcomes.

Indexed as

follow-upinfluenza A(H1N1)pdm09influenza A(H3N2)influenza Boutcomes

Identifiers

PMID29308401
PMCPMC5740982
OpenAlexW2783327453

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.