ArticleCurrent sleep medicine reports2017
Circadian Rhythms in AD pathogenesis: A Critical Appraisal.
Article in Current sleep medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of tau pathology.Experimental neurology · 2025Article
- Circadian rhythms are associated with higher amyloid-β and tau and poorer cognition in older adults.Brain communications · 2025Article
- Integrated Transcriptomics and Network Analysis Identified Altered Neural Mechanisms in Frontal Aging Brain-Associated Alzheimer's Disease.Biochemical genetics · 2024Article
- Outdoor nighttime light exposure (light pollution) is associated with Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping.iScience · 2023Article
- Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer's disease.Acta neuropathologica communications · 2023Article
- Oxidative Stress and Aging as Risk Factors for Alzheimer's Disease and Parkinson's Disease: The Role of the Antioxidant Melatonin.International journal of molecular sciences · 2023Review
- SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders.Aging clinical and experimental research · 2022Review
- The Effects of Light and the Circadian System on Rhythmic Brain Function.International journal of molecular sciences · 2022Review
- Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease.Neuroscience · 2022Article
- Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling.Ageing research reviews · 2022Review
- Effect of a dynamic lighting intervention on circadian rest-activity disturbances in cognitively impaired, older adults living in a nursing home: A proof-of-concept study.Neurobiology of sleep and circadian rhythms · 2021Article
- Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice.Neurobiology of disease · 2021Article
- Early alterations of neurovascular unit in the retina in mouse models of tauopathy.Acta neuropathologica communications · 2021Article
- Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.EBioMedicine · 2020Article
- Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway.Frontiers in aging neuroscience · 2020Review
- Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms.Neural plasticity · 2018Review
- 'Developmental Delay' Reconsidered: The Critical Role of Age-Dependent, Co-variant Development.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
purpose of the reviewA wide array of sleep and circadian deficits have been observed in patients with Alzheimer's Disease (AD). However, the vast majority of these studies have focused on later-stage AD, and do not shed light on the possibility that circadian dysfunction contributes to AD pathogenesis. The goal of this review it to examine the evidence supporting or refuting the hypothesis that circadian dysfunction plays an important role in early AD pathogenesis or AD risk in humans. RECENT
findingsFew studies have addressed the role of the circadian system in very early AD, or prior to AD diagnosis. AD appears to have a long presymtomatic phase during which pathology is present but cognition remains normal. Studies evaluating circadian function in cognitively-normal elderly or early-stage AD have thus far not incorporated AD biomarkers. Thus, the cause-and-effect relationship between circadian dysfunction and early-stage AD remains unclear. SUMMARY: Circadian dysfunction becomes apparent in AD as dementia progresses, but it is unknown at which point in the pathogenic process rhythms begin to deteriorate. Further, it is unknown if exposure to circadian disruption in middle age increases AD risk later in life. This review address gaps in current knowledge on this topic, and proposes several critical directions for future research which might help to clarify the potential pathogenic role of circadian clock dysfunction in AD.
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