Evidence map›Paper›PMID 29308330›Full record

ArticleFatigue : biomedicine, health & behavior2017

Elevations of Ventricular Lactate Levels Occur in Both Chronic Fatigue Syndrome and Fibromyalgia.

Benjamin H Natelson, Diana Vu, Jeremy D Coplan, Xiangling Mao, Michelle Blate, Guoxin Kang, Eli Soto, Tolga Kapusuz, Dikoma C Shungu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fatigue : biomedicine, health & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  10. Review of Neuroimaging Methods in ME/CFS.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Benjamin H NatelsonDepartment of Neurology, Mount Sinai Beth Israel, New York, NY.
Diana VuDepartment of Neurology, Mount Sinai Beth Israel, New York, NY.
Jeremy D CoplanDepartment of Psychiatry & Behavioral Sciences, State University of New York-Downstate Medical Center, Brooklyn NY.
Xiangling MaoDepartment of Radiology, Weill Medical College of Cornell University, New York, NY.
Michelle BlateDepartment of Neurology, Mount Sinai Beth Israel, New York, NY.
Guoxin KangDepartment of Radiology, Weill Medical College of Cornell University, New York, NY.
Eli SotoDepartment of Pain Medicine, Mount Sinai Beth Israel, New York, NY.
Tolga KapusuzDepartment of Pain Medicine, Mount Sinai Beth Israel, New York, NY.
Dikoma C ShunguDepartment of Radiology, Weill Medical College of Cornell University, New York, NY.
Mount Sinai Beth Israel · USWeill Cornell Medicine · USCornell University · USState University of New York · US

Funding

3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Specificity and Validity of Oxidative Stress Model of Chronic Fatigue SyndromeR01MH100005 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHUNGU, DIKOMA C · 2013 to 2016
$2.0M
Neuropathologic Abnormalities Define A Subgroup of Patients with CFSR21NS075653 · NINDS · BETH ISRAEL MEDICAL CTR (NEW YORK) · PI NATELSON, BENJAMIN, WEIDUSCHAT, NORA · 2011 to 2012
$512k
NIH HHS S10 OD021782NIMH NIH HHS R01 MH100005NINDS NIH HHS R21 NS075653
6 · The paper itself

Abstract

backgroundChronic fatigue syndrome (CFS) and fibromyalgia (FM) frequently have overlapping symptoms, leading to the suggestion that the same disease processes may underpin the two disorders - the unitary hypothesis. However, studies investigating the two disorders have reported substantial clinical and/or biological differences between them, suggesting distinct pathophysiological underpinnings. PURPOSE: The purpose of this study was to further add to the body of evidence favoring different disease processes in CFS and FM by comparing ventricular cerebrospinal fluid lactate levels among patients with CFS alone, FM alone, overlapping CFS and FM symptoms, and healthy control subjects.

methodsVentricular lactate was assessed

resultsMean CSF lactate levels in CFS, FM and CFS+FM did not differ among the three groups, but were all significantly higher than the mean values for control subjects.

conclusionWhile patients with CFS, FM and comorbid CFS and FM can be differentiated from healthy subjects based on measures of CFS lactate, this neuroimaging outcome measure is not a viable biomarker for differentiating CFS from FM or from patients in whom symptoms of the two disorders overlap.

Identifiers

PMID29308330
PMCPMC5754037
OpenAlexW2591212997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.