Evidence map›Paper›PMID 29307950›Full record

ArticleMaterials & design2018

Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging.

Feng-Lei Zhou, Zhanxiong Li, Julie E Gough, Penny L Hubbard Cristinacce, Geoff J M Parker

Abstract read
In one paragraph

Article in Materials & design, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feng-Lei ZhouDivision of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom.
Zhanxiong LiCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215000, PR China.
Julie E GoughThe School of Materials, The University of Manchester, Manchester M13 9PL, United Kingdom.
Penny L Hubbard CristinacceSchool of Psychological Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom.
Geoff J M ParkerDivision of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom.

Funding

Cancer Research UK 16465Cancer Research UK 18097Wellcome Trust
6 · The paper itself

Abstract

Highly hydrophilic hollow polycaprolactone (PCL) microfibres were developed as building elements to create tissue-mimicking test objects (phantoms) for validation of diffusion magnetic resonance imaging (MRI). These microfibres were fabricated by the co-electrospinning of PCL-polysiloxane-based surfactant (PSi) mixture as shell and polyethylene oxide as core. The addition of PSi had a significant effect on the size of resultant electrospun fibres and the formation of hollow microfibres. The presence of PSi in both co-electrospun PCL microfibre surface and cross-section, revealed by X-ray energy dispersive spectroscopy (EDX), enabled water to wet these fibres completely (i.e., zero contact angle) and remained active for up to 12 months after immersing in water. PCL and PCL-PSi fibres with uniaxial orientation were constructed into water-filled phantoms. MR measurement revealed that water molecules diffuse anisotropically in the PCL-PSi phantom. Co-electrospun hollow PCL-PSi microfibres have desirable hydrophilic properties for the construction of a new generation of tissue-mimicking dMRI phantoms.

Indexed as

Axon mimicCo-electrospinningDiffusion magnetic resonance imagingHydrophilic hollow microfibresPolycaprolactone

Identifiers

PMID29307950
PMCPMC5727678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.