Evidence map›Paper›PMID 29307736›Full record

ReviewExperimental gerontology2018

Fluid and imaging biomarkers for Alzheimer's disease: Where we stand and where to head to.

Adriane Dallanora Henriques, Andrea Lessa Benedet, Einstein Francisco Camargos, Pedro Rosa-Neto, Otávio Toledo Nóbrega

Abstract readReview
In one paragraph

Review in Experimental gerontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Gut Microbiota and Immunotherapy for Alzheimer's Disease.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Neuroimaging Biomarkers for Alzheimer's Disease.Molecular neurodegeneration · 2019
    Review
  17. Delirium and Alzheimer disease: A proposed model for shared pathophysiology.International journal of geriatric psychiatry · 2019
    Article
  18. Article
  19. Review
  20. The Yale journal of biology and medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adriane Dallanora HenriquesMedical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900 Brasília, DF, Brazil.
Andrea Lessa BenedetTranslational Neuroimaging Laboratory, Research Centre for Studies in Aging, Douglas Hospital, McGill University, H4H 1R3 Montreal, QC, Canada.
Einstein Francisco CamargosMedical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900 Brasília, DF, Brazil.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, Research Centre for Studies in Aging, Douglas Hospital, McGill University, H4H 1R3 Montreal, QC, Canada; Montreal Neurological Institute, H3A 2B4 Montreal, QC, Canada.
Otávio Toledo NóbregaMedical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900 Brasília, DF, Brazil. Electronic address: otavionobrega@unb.br.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
Resource for MRI of Neurodegenerative DisordersP41EB015904 · NIBIB · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI WEINER, MICHAEL W · 2012 to 2012
$1.2M
CIHR MOP-11-51-31CIHR RFN 152985NIA NIH HHS U19 AG024904NIBIB NIH HHS P41 EB015904
6 · The paper itself

Abstract

There is increasing evidence that a number of potentially informative biomarkers for Alzheimer disease (AD) can improve the accuracy of diagnosing this form of dementia, especially when used as a panel of diagnostic assays and interpreted in the context of neuroimaging and clinical data. Moreover, by combining the power of CSF biomarkers with neuroimaging techniques to visualize Aβ deposits (or neurodegenerative lesions), it might be possible to better identify individuals at greatest risk for developing MCI and converting to AD. The objective of this article was to review recent progress in selected imaging and chemical biomarkers for prediction, early diagnosis and progression of AD. We present our view point of a scenario that places CSF and imaging markers on the verge of general utility based on accuracy levels that already match (or even surpass) current clinical precision.

Indexed as

AgedAlzheimer DiseaseBiomarkersBrainCerebrospinal FluidCognitive DysfunctionDisease ProgressionEarly DiagnosisHumansNeuroimagingBiomarkersAlzheimerBiomarkerCerebrospinal fluidDiagnosisMild cognitive impairmentNeuroimaging

Identifiers

PMID29307736
PMCPMC5951730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.