ArticleNeuron2018
Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type.bioRxiv : the preprint server for biology · 2026Article
- Article
- SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.eLife · 2026Article
- Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior.bioRxiv : the preprint server for biology · 2026Article
- Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity.Current biology : CB · 2026Article
- The vab-1/Eph receptor and ephrins efn-1 and efn-4 are required for C. elegans chemosensory and thermosensory circuit assembly and function.BMC neuroscience · 2025Article
- A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans.Nature communications · 2025Article
- Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning.Nature communications · 2025Article
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Review
- Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.Nature communications · 2024Article
- A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Understanding neural circuit function through synaptic engineering.Nature reviews. Neuroscience · 2024Review
- The AFD-expressed SRTX-1 GPCR does not contribute to AFD thermosensory functions.microPublication biology · 2024Article
- Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adaptation in a single thermosensory neuron type.bioRxiv : the preprint server for biology · 2023Article
- Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line.G3 (Bethesda, Md.) · 2023Article
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Authors and funding
13 authors.
Funding
Abstract
Neural plasticity, the ability of neurons to change their properties in response to experiences, underpins the nervous system's capacity to form memories and actuate behaviors. How different plasticity mechanisms act together in vivo and at a cellular level to transform sensory information into behavior is not well understood. We show that in Caenorhabditis elegans two plasticity mechanisms-sensory adaptation and presynaptic plasticity-act within a single cell to encode thermosensory information and actuate a temperature preference memory. Sensory adaptation adjusts the temperature range of the sensory neuron (called AFD) to optimize detection of temperature fluctuations associated with migration. Presynaptic plasticity in AFD is regulated by the conserved kinase nPKCε and transforms thermosensory information into a behavioral preference. Bypassing AFD presynaptic plasticity predictably changes learned behavioral preferences without affecting sensory responses. Our findings indicate that two distinct neuroplasticity mechanisms function together through a single-cell logic system to enact thermotactic behavior. VIDEO ABSTRACT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.