Evidence map›Paper›PMID 29307689›Full record

ArticleThe Journal of pediatrics2018

Fifteen-Year Trends in Pediatric Liver Transplants: Split, Whole Deceased, and Living Donor Grafts.

Douglas B Mogul, Xun Luo, Mary G Bowring, Eric K Chow, Allan B Massie, Kathleen B Schwarz, Andrew M Cameron, John F P Bridges, Dorry L Segev

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  13. Organ allocation in pediatric abdominal transplant.Seminars in pediatric surgery · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Douglas B MogulDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: dmogul1@jhmi.edu.
Xun LuoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Mary G BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Eric K ChowDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Kathleen B SchwarzDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Andrew M CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
John F P BridgesDepartment of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.

Funding

Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Improving pediatric liver transplant allocationK08HS023876 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI MOGUL, DOUGLAS · 2015 to 2019
$787k
AHRQ HHS K08 HS023876NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

objectiveTo evaluate changes in patient and graft survival for pediatric liver transplant recipients since 2002, and to determine if these outcomes vary by graft type (whole liver transplant, split liver transplant [SLT], and living donor liver transplant [LDLT]). STUDY

designWe evaluated patient and graft survival among pediatric liver-only transplant recipients the PELD/MELD system was implemented using the Scientific Registry of Transplant Recipients.

resultsFrom 2002-2009 to 2010-2015, survival for SLT at 30 days improved (94% vs 98%; P < .001), and at 1 year improved for SLT (89% to 95%; P <.001) and LDLT (93% to 98%; P = .002). There was no change in survival for whole liver transplant at either 30 days (98% in both; P = .7) or 1 year (94% vs 95%; P = .2). The risk of early death with SLT was 2.14-fold higher in 2002-2009 (adjusted hazard ratio [aHR] vs whole liver transplant,

conclusionsIn recent years, outcomes after the use of technical variant grafts are comparable with whole grafts, and may be superior for LDLT. Greater use of technical variant grafts might provide an opportunity to increase organ supply without compromising post-transplant outcomes.

Indexed as

Living DonorsAdolescentChildChild, PreschoolDatabases, FactualFemaleGraft SurvivalHumansInfantInfant, NewbornLiverLiver FailureLiver TransplantationMalePediatricsTissue Donorsallograftliverpediatricsplittransplant

Identifiers

PMID29307689
PMCPMC5924625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.