ArticleNeurobiology of disease2018
Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease.
Article in Neurobiology of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Pallidal deep brain stimulation modulates excessive cortical high β phase amplitude coupling in Parkinson disease.Brain stimulationTrial
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Article
- Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions.Brain : a journal of neurology · 2023Review
- Subthalamic and nigral neurons are differentially modulated during parkinsonian gait.Brain : a journal of neurology · 2023Article
- Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson's disease patient on chronic deep brain stimulation.Frontiers in neurology · 2023Article
- Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium.Cell reports · 2022Article
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- Finely-tuned gamma oscillations: Spectral characteristics and links to dyskinesia.Experimental neurology · 2022Review
- Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat.Frontiers in aging neuroscience · 2022Article
- Brain Dynamics Underlying Preserved Cycling Ability in Patients With Parkinson's Disease and Freezing of Gait.Frontiers in psychology · 2022Review
- Attenuation of neural responses in subthalamic nucleus during internally guided voluntary movements in Parkinson's disease.Frontiers in human neuroscience · 2022Article
- Combined Subthalamic and Nigral Stimulation Modulates Temporal Gait Coordination and Cortical Gait-Network Activity in Parkinson's Disease.Frontiers in human neuroscience · 2022Article
- Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Closing the loop of DBS using the beta oscillations in cortex.Cognitive neurodynamics · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Pathological synchronisation of beta frequency (12-35Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influence the firing of STN neurons and, consequently, their downstream targets. Here, we examined the dynamics of synchronisation between STN LFPs and units with multiple cortical areas, measured using frontal ECoG, midline EEG and lateral EEG, during rest and movement. STN neurons lagged cortical signals recorded over midline (over premotor cortices) and frontal (over prefrontal cortices) with stable time delays, consistent with strong corticosubthalamic drive, and many neurons maintained these dynamics during movement. In contrast, most STN neurons desynchronised from lateral EEG signals (over primary motor cortices) during movement and those that did not had altered phase relations to the cortical signals. The strength of synchronisation between STN units and midline EEG in the high beta range (25-35Hz) correlated positively with the severity of akinetic-rigid motor symptoms across patients. Together, these results suggest that sustained synchronisation of STN neurons to premotor-cortical beta oscillations play an important role in disrupting the normal coding of movement in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.