Evidence map›Paper›PMID 29307589›Full record

ArticleJournal of autoimmunity2018

Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.

Flor Evangelista, Aleeza J Roth, Phillip Prisayanh, Brenda R Temple, Ning Li, Ye Qian, Donna A Culton, Zhi Liu, Oliver J Harrison, Julia Brasch and 3 more

Abstract read
In one paragraph

Article in Journal of autoimmunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Cadherin Signaling in Cancer and Autoimmune Diseases.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Fogo selvagem: endemic pemphigus foliaceus.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Flor EvangelistaDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Laboratorio de Investigación Multidisciplinaria, Universidad Antenor Orrego, Trujillo, Peru.
Aleeza J RothPathology Diagnostic Liaison-Northeast Region, Bristol-Myers Squibb, Princeton NJ, USA.
Phillip PrisayanhDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brenda R TempleDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; R.L. Juliano Structural Bioinformatics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ning LiDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ye QianDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Donna A CultonDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhi LiuDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oliver J HarrisonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA.
Julia BraschCenter for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA.
Barry HonigDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA; Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA; Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA; Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Luis A DiazDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: ldiaz@med.unc.edu.
University of North Carolina at Chapel Hill · USColumbia University · USBristol-Myers Squibb (United States) · USHoward Hughes Medical Institute · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSR01AR032599 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIAZ, LUIS A. · 1987 to 2017
$5.2M
IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOIDR01AI040768 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 2001 to 2016
$4.1M
Eosinophils in Bullous PemphigoidR01AR070276 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 2017 to 2021
$1.9M
Structure and Function of Desmosomal CadherinsR01GM118584 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRO, LAWRENCE S · 2017 to 2020
$1.8M
Innate Immunity in Bullous PemphigoidR01AI079240 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 2010 to 2014
$1.8M
The IgE Antibody Response to Dsg1 and Environmental Antigens in Endemic Pemphigus FoliaceusR01AR067315 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI QIAN, YE · 2015 to 2019
$1.7M
Role of the matrix metalloproteinase in pemphigus autoantibody-mediated epidermalR01AR061372 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, NING · 2012 to 2016
$1.5M
IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOIDR29AI040768 · NIAID · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI LIU, ZHI · 1996 to 2000
$101k
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI040768NIAID NIH HHS R01 AI079240NIAID NIH HHS R29 AI040768NIAMS NIH HHS R01 AR032599NIAMS NIH HHS R01 AR061372NIAMS NIH HHS R01 AR067315NIAMS NIH HHS R01 AR070276NIGMS NIH HHS R01 GM118584
6 · The paper itself

Abstract

Fogo Selvagem (FS), the endemic form of pemphigus foliaceus, is mediated by pathogenic IgG4 autoantibodies against the amino-terminal extracellular cadherin domain of the desmosomal cadherin desmoglein 1 (Dsg1). Here we define the detailed epitopes of these pathogenic antibodies. Proteolytic footprinting showed that IgG4 from 95% of FS donor sera (19/20) recognized a 16-residue peptide (A

Indexed as

AnimalsAutoantibodiesBrazilCells, CulturedDesmoglein 1DesmosomesEndemic DiseasesEpitope MappingEpitopes, B-LymphocyteHumansImmunization, PassiveImmunoglobulin GMiceMice, Inbred BALB CMutagenesis, Site-DirectedPemphigusAutoantibodiesDesmoglein 1Epitopes, B-LymphocyteImmunoglobulin GPeptidesCell adhesion moleculeDesmosomeIgG4 autoantibodySkin autoimmunity

Identifiers

PMID29307589
PMCPMC5902409
OpenAlexW2782099172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.