Evidence map›Paper›PMID 29307580›Full record

ArticleStem cell reports2018

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner.

Paul V Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B Graca, Claire Hippert, Nozie D Aghaizu, Aikaterini A Kalargyrou, Amanda C Barber, Giulia Grimaldi and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Review
  2. Review
  3. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  4. Review
  5. Global Treatment Approaches Part 1: Neuroprotection and Stem Cell Therapy.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Stem cell therapy in retinal diseases.Neural regeneration research · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Paul V WaldronUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Fabiana Di MarcoStem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Kamil KruczekUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Joana RibeiroUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Anna B GracaUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Claire HippertUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Nozie D AghaizuUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Aikaterini A KalargyrouUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Amanda C BarberUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Giulia GrimaldiStem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Yanai DuranUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Samuel J I BlackfordUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Magdalena KlocUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Debbie GohUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Eduardo Zabala AldunateStem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Robert D SampsonUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
James W B BainbridgeUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Alexander J SmithUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Anai Gonzalez-CorderoUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Jane C SowdenStem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Robin R AliUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Rachael A PearsonUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: rachael.pearson@ucl.ac.uk.

Funding

Department of Health NIHR-RP-011-003Medical Research Council MR/J004553/1Medical Research Council MR/L012758/1Medical Research Council MR/M007871/1Wellcome Trust
6 · The paper itself

Abstract

Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process previously understood to arise by donor cell integration within the host retina. However, we and others recently demonstrated that donor rod photoreceptors engage in material transfer with host photoreceptors, leading to the host cells acquiring proteins otherwise expressed only by donor cells. We sought to determine whether stem cell- and donor-derived cones undergo integration and/or material transfer. We find that material transfer accounts for a significant proportion of rescued cells following cone transplantation into non-degenerative hosts. Strikingly, however, substantial numbers of cones integrated into the Nrl

Indexed as

Stem Cell TransplantationAnimalsBasic-Leucine Zipper Transcription FactorsBlindnessCell Differentiationcis-trans-IsomerasesDisease Models, AnimalEye ProteinsHumansMicePeripherinsRetinaRetinal Cone Photoreceptor CellsRetinal DegenerationRetinoid IsomerohydrolaseStem CellsBasic-Leucine Zipper Transcription Factorscis-trans-IsomerasesEye ProteinsNrl protein, mousePeripherinsPrph2 protein, mouseRetinoid Isomerohydrolaseblindnessfunctionfusionintegrationmaterial transferNrl(−/−)photoreceptorretinaretinal dystrophytransplantation

Identifiers

PMID29307580
PMCPMC5830910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.