ArticleJournal of molecular and cellular cardiology2018
Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca
Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Extracellular Vesicles in Diabetic Cardiomyopathy-State of the Art and Future Perspectives.International journal of molecular sciences · 2024Review
- Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics.Open medicine (Warsaw, Poland) · 2023Article
- The Physiology and Pathophysiology of T-Tubules in the Heart.Frontiers in physiology · 2021Review
- Nexilin is a New Player for Shaping T-Tubules in Cardiomyocytes.Circulation. Heart failure · 2020Article
- Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function.Chinese medical journal · 2018Article
- Dyadic Plasticity in Cardiomyocytes.Frontiers in physiology · 2018Review
- Cholesterol Protects Against Acute Stress-Induced T-Tubule Remodeling in Mouse Ventricular Myocytes.Frontiers in physiology · 2018Article
- Influence of verapamil on pressure overload-induced ventricular arrhythmias by regulating gene-expression profiles.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsProtein kinase C (PKC) isozymes contribute to the development of heart failure through dysregulation of Ca METHODS AND
resultsShortly upon ventricular pressure overload in mice, we detected transient PKC activation that was associated with pulsed actin cytoskeletal rearrangement. In cultured cardiomyocytes, transient activation of PKC promoted long-term deleterious effects on the integrity of the transverse (T)- tubule system, resulting in a significant decrease in the amplitude and increase in the rising kinetics of Ca
conclusionsThese data identify a key mechanistic link between transient PKC activation and long-term Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.