ArticleFertility and sterility2018
Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy.
Article in Fertility and sterility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03940495 (A Prospective Study to Evaluate Whether Serum Kisspeptin is a Marker Predictive of the First Trimester Miscarriage of Women Who Conceive in IVF), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Study to Evaluate Whether Serum Kisspeptin is a Marker Predictive of the First Trimester Miscarriage of Women Who Conceive in IVF
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- The arginine-phenylalanine-amide neuropeptide receptor family: Physiological effects, drug development, and structural insights.Neural regeneration research · 2026Article
- Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.Drug testing and analysis · 2026Article
- Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability.Pharmacy (Basel, Switzerland) · 2026Review
- The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.International journal of molecular sciences · 2026Review
- Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Kisspeptin and neurokinin B: roles in reproductive health.Physiological reviews · 2025Review
- Evaluation of novel biomarkers for early pregnancy outcome prediction†.Biology of reproduction · 2024Article
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.Endocrine reviews · 2024Review
- A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.Journal of assisted reproduction and genetics · 2024Article
- Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats.International journal of molecular sciences · 2023Article
- The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review.International journal of molecular sciences · 2022Review
- Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction.Reproductive biology and endocrinology : RB&E · 2022Review
- Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model.Frontiers in endocrinology · 2022Article
- Kisspeptin in the Prediction of Pregnancy Complications.Frontiers in endocrinology · 2022Review
- The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.Frontiers in endocrinology · 2022Review
- Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.Fertility and sterility · 2021Article
- From inhibition of trophoblast cell invasion to proapoptosis: what are the potential roles of kisspeptins in preeclampsia?American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions.Medeniyet medical journal · 2021Article
- Is placental KISS-1 expression associated with first trimester abortion spontaneous?Obstetrics & gynecology science · 2020Article
- Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery.Reproductive biology and endocrinology : RB&E · 2019Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo validate the ability of serum kisspeptin-54 to discriminate between first-trimester viable pregnancies and miscarriages.
designCase-control study.
settingAcademic medical centers. PATIENT(S): Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19). INTERVENTION(S): Collection of serum samples from women with confirmed IUP, SAB, and nonpregnant women for the measurement of serum kisspeptin and serum hCG levels. MAIN OUTCOME MEASURE(S): Serum kisspeptin and hCG. RESULT(S): The limit of detection was 0.024 ng/mL; intra- and interassay coefficients of variation were 5.1% and 8.6%, respectively. Kisspeptin levels differed between the pregnant and nonpregnant state and by viability. Kisspeptin levels were positively associated with gestational age. There was also a significant positive association with hCG in SAB, but not in IUP. CONCLUSION(S): Plasma levels of kisspeptin have been suggested as a biomarker for miscarriage. This study demonstrates kisspeptin assay stability in serum and its potential clinical utility as a biomarker for early pregnancy viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.