Evidence map›Paper›PMID 29307255›Full record

ArticleInternational journal of radiation biology2018

Bioavailable serum estradiol may alter radiation risk of postmenopausal breast cancer: a nested case-control study.

Eric J Grant, John B Cologne, Gerald B Sharp, Hidetaka Eguchi, Richard G Stevens, Shizue Izumi, Young-Min Kim, Amy Berrington de González, Waka Ohishi, Kei Nakachi

Abstract read
In one paragraph

Article in International journal of radiation biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Eric J Granta Radiation Effects Research Foundation , Hiroshima , Japan.
John B Cologneb Department of Statistics , Radiation Effects Research Foundation , Hiroshima , Japan.
Gerald B Sharpc Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Epidemiology Branch, Basic Sciences Program , Bethesda , MD , USA.
Hidetaka Eguchid Translational Research Division , Research Center for Genomic Medicine, Saitama Medical University , Saitama , Japan.
Richard G Stevense Department of Community Medicine , University of Connecticut Health Center , Farmington, CT , USA.
Shizue Izumif Center for Data Science Education and Research, Shiga University , Hikone , Japan.
Young-Min Kimg Department of Statistics, College of Natural Science , Kyungpook National University , Daegu , South Korea.
Amy Berrington de Gonzálezh Division of Cancer Epidemiology and Genetics , NCI/NIH , Bethesda , MD , USA.
Waka Ohishii Department of Clinical Studies , Radiation Effects Research Foundation , Hiroshima , Japan.
Kei Nakachij Department of Molecular Biosciences , Radiation Effects Research Foundation , Hiroshima , Japan.
Radiation Effects Research Foundation · JPDivision of Cancer Epidemiology and GeneticsKyungpook National University · KRNational Institute of Allergy and Infectious Diseases · USSaitama Medical University · JPShiga University · JPUConn Health · US

Funding

NCI NIH HHS HHSN261200900005CNCI NIH HHS HHSN261201400009C
6 · The paper itself

Abstract

purposeIonizing radiation and high levels of circulating estradiol are known breast cancer carcinogens. We investigated the risk of first primary postmenopausal breast cancer in relation to the combined effects of whole-body ionizing radiation exposure and prediagnostic levels of postmenopausal sex hormones, particularly bioavailable estradiol (bE MATERIALS AND

methodsA nested case-control study of 57 incident breast cancer cases matched with 110 controls among atomic bomb survivors. Joint effects of breast radiation dose and circulating levels of sex hormones were assessed using binary regression and path analysis. RESULTS AND

conclusionRadiation exposure, higher levels of bE

Indexed as

AdultAgedBiological AvailabilityBreast NeoplasmsCase-Control StudiesDNA DamageEstradiolFemaleHumansLongitudinal StudiesMiddle AgedNeoplasms, Radiation-InducedPostmenopauseProgesteroneRadiation, IonizingRadiometryEstradiolProgesteroneTestosteroneBreast cancerestradiolhormonesinteractionmediationpostmenopausalradiation

Identifiers

PMID29307255
PMCPMC6135639
OpenAlexW2784309940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.