Evidence map›Paper›PMID 29306999›Full record

ArticleParasitology research2018

Assessment of the antiprotozoal activity of Pulicaria inuloides extracts, an Algerian medicinal plant: leishmanicidal bioguided fractionation.

Hamza Fadel, Ines Sifaoui, Atteneri López-Arencibia, María Reyes-Batlle, Soumaya Hajaji, Olfa Chiboub, Ignacio A Jiménez, Isabel L Bazzocchi, Jacob Lorenzo-Morales, Samir Benayache and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. A Comprehensive Review on Anticancer Potential ofCurrent cancer drug targets · 2025
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  4. Constituents ofMolecules (Basel, Switzerland) · 2023
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  5. Antioxidant and Leishmanicidal Evaluation ofPathogens (Basel, Switzerland) · 2019
    Article
  6. Withanolides fromPathogens (Basel, Switzerland) · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Hamza FadelUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimique et Biologiques, Université Constantine-1, Route d'Ain El Bey, 25 000, Constantine, Algeria.
Ines SifaouiUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
Atteneri López-ArencibiaUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
María Reyes-BatlleUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
Soumaya HajajiLaboratoire de Parasitologie, École Nationale de Médecine Vétérinaire de Sidi Thabet, Université de la Manouba, 2020, Sidi Thabet, Tunisia.
Olfa ChiboubUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
Ignacio A JiménezInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Isabel L BazzocchiInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Jacob Lorenzo-MoralesUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain. JMLORENZ@ULL.EDU.ES.ORCID http://orcid.org/0000-0002-7683-2888
Samir BenayacheUnité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimique et Biologiques, Université Constantine-1, Route d'Ain El Bey, 25 000, Constantine, Algeria.
José E PiñeroUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda. Astrofısico Fco. Sanchez, S/N, 38203, La Laguna, Tenerife, Canary Islands, Spain.
Universidad de La Laguna · ESUniversity Frères Mentouri Constantine 1 · DZManouba University · TN

Funding

Instituto de Salud Carlos III RICET (project RD12/0018/0012Ministerio de Ciencia e Innovación SAF 2015-65113-C2-1-RMinistry of Higher Education and Scientific Research of Algeria 2017Obra Social La Caixa-Fundación CajaCanarias BIO24Universidad de La Laguna Plan Propio 2017
6 · The paper itself

Abstract

The lack of an effective chemotherapy for treatment of protozoan disease urges a wide investigation for active compounds, and plant-derived compounds continue to provide key leads for therapeutic agents. The current study reports the in vitro antiprotozoal evaluation of the Algerian medicinal plant Pulicaria inuloides against Leishmania amazonensis, Trypanosoma cruzi, and Acanthamoeba castellanii str. Neff. All the extracts from the aerial part showed to be present a higher leishmanicidal activity than anti-Acanthamoeba or Trypanosoma. Therefore, bioguided fractionation of the active CHCl

Indexed as

Acanthamoeba castellaniiAlgeriaAnimalsChemical FractionationFlavonoidsLeishmania mexicanaPlant ExtractsPlants, MedicinalPulicariaTrypanocidal AgentsTrypanosoma cruzi3-hydroxyflavoneFlavonoidsPlant ExtractsTrypanocidal AgentsAcanthamoebaBioguided fractionationLeishmaniaPulicaria inuloidesTrypanosoma

Identifiers

PMID29306999
OpenAlexW2782384602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.