Evidence map›Paper›PMID 29306874›Full record

ArticleThe Journal of biological chemistry2018

A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).

Nienke W M de Jong, Nicoleta T Ploscariu, Kasra X Ramyar, Brandon L Garcia, Alvaro I Herrera, Om Prakash, Benjamin B Katz, Kevin G Leidal, William M Nauseef, Kok P M van Kessel and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Human neutrophilsImmunological reviews · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Group BJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  12. Regulation of Amino Acid Transport in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2019
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nienke W M de JongFrom Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Nicoleta T Ploscariuthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Kasra X Ramyarthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Brandon L Garciathe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Alvaro I Herrerathe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Om Prakashthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Benjamin B Katzthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Kevin G Leidalthe Inflammation Program, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52240, and.
William M Nauseefthe Inflammation Program, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52240, and.
Kok P M van KesselFrom Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Jos A G van StrijpFrom Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Brian V Geisbrechtthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506, GeisbrechtB@ksu.edu.
Kansas State University · USUniversity Medical Center Utrecht · NLUniversity of Iowa · US

Funding

Consequences of interactions between human neutrophils and Staphylococcus aureusR01AI116546 · NIAID · UNIVERSITY OF IOWA · PI NAUSEEF, WILLIAM M. · 2015 to 2019
$1.8M
Novel Staphylococcal Inhibitors of Neutrophil Granule EnzymesR01GM121511 · NIGMS · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2017 to 2020
$1.2M
Inhibition of the Classical & Lectin Complement Pathways by Staphylococcus aureus EapR21AI111203 · NIAID · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2015 to 2016
$375k
Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responsesI01BX000513 · VA · IOWA CITY VA MEDICAL CENTER · PI NAUSEEF, WILLIAM M. · 2009 to 2017
–
BLRD VA I01 BX000513NIAID NIH HHS R01 AI116546NIAID NIH HHS R21 AI111203NIGMS NIH HHS R01 GM121511
6 · The paper itself

Abstract

The heme-containing enzyme myeloperoxidase (MPO) is critical for optimal antimicrobial activity of human neutrophils. We recently discovered that the bacterium

Indexed as

Amino Acid MotifsBacterial ProteinsCrystallography, X-RayHumansMagnetic Resonance SpectroscopyPeroxidaseProtein BindingStaphylococcal InfectionsStaphylococcus aureusBacterial ProteinsMPO protein, humanPeroxidaseimmune evasioninnate immunitymyeloperoxidaseneutrophilprotein–protein interactionSPINStaphylococcus aureus (S. aureus)

Identifiers

PMID29306874
PMCPMC5818189
OpenAlexW2782094194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.