Evidence map›Paper›PMID 29306820›Full record

ReviewCurrent opinion in chemical biology2018

Activity-based sensing fluorescent probes for iron in biological systems.

Allegra T Aron, Audrey G Reeves, Christopher J Chang

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 107 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The Labile Side of Iron in Health and Disease: A Narrative Review.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Construction of novel π-bridged fluorescent probes for FeAnalytical and bioanalytical chemistry · 2024
    Article
  8. Review
  9. A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Elucidating Iron Metabolism through Molecular Imaging.Current issues in molecular biology · 2024
    Review
  12. Article
  13. Imaging-Selected Host Responses in the Context of Infections.The Journal of infectious diseases · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Iron homeostasis and organismal aging.Ageing research reviews · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Allegra T AronDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
Audrey G ReevesDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
Christopher J ChangDepartment of Chemistry, University of California, Berkeley, CA 94720, USA; Departments of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. Electronic address: chrischang@berkeley.edu.
University of California, Berkeley · US

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM079465NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe

Indexed as

BiomimeticsEpigenesis, GeneticFerrous CompoundsFluorescent DyesHumansIron-Binding ProteinsOxidation-ReductionOxidative StressOxidesFerrous CompoundsFluorescent DyesIron-Binding ProteinsOxides

Identifiers

PMID29306820
PMCPMC5847483
OpenAlexW2782436857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.