ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.Molecular psychiatry · 2023Article
- Systems Genetic Identification of Mitochondrion-Associated Alzheimer's Disease Genes and Implications for Disease Risk Prediction.Biomedicines · 2022Article
- Mitochondrial Genetics Reinforces Multiple Layers of Interaction in Alzheimer's Disease.Biomedicines · 2022Article
- Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Prediction of Conversion from CIS to Clinically Definite Multiple Sclerosis Using Convolutional Neural Networks.Computational and mathematical methods in medicine · 2022Article
- A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change.Journal of Alzheimer's disease : JAD · 2022Article
- A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants.BMC bioinformatics · 2021Article
- The Other Side of Alzheimer's Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers.Journal of personalized medicine · 2020Review
- Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Mitonuclear interactions influence Alzheimer's disease risk.Neurobiology of aging · 2020Article
- Mitochondria and Alzheimer's Disease: the Role of Mitochondrial Genetic Variation.Current genetic medicine reports · 2018Review
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Authors and funding
7 authors.
Funding
Abstract
introductionMitochondrial genetics are an important but largely neglected area of research in Alzheimer's disease. A major impediment is the lack of data sets.
methodsWe used an innovative, rigorous approach, combining several existing tools with our own, to accurately assemble and call variants in 809 whole mitochondrial genomes.
resultsTo help address this impediment, we prepared a data set that consists of 809 complete and annotated mitochondrial genomes with samples from the Alzheimer's Disease Neuroimaging Initiative. These whole mitochondrial genomes include rich phenotyping, such as clinical, fluid biomarker, and imaging data, all of which is available through the Alzheimer's Disease Neuroimaging Initiative website. Genomes are cleaned, annotated, and prepared for analysis. DISCUSSION: These data provide an important resource for investigating the impact of mitochondrial genetic variation on risk for Alzheimer's disease and other phenotypes that have been measured in the Alzheimer's Disease Neuroimaging Initiative samples.
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