ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Regional vulnerability in Alzheimer's disease: The role of cell-autonomous and transneuronal processes.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer's disease mouse model.bioRxiv : the preprint server for biology · 2026Article
- Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-bioRxiv : the preprint server for biology · 2026Article
- Back to the Future: Predicting Individual Tau Progression in Alzheimer's Disease.Research square · 2025Article
- Connectome-based biophysical models of pathological protein spreading in neurodegenerative diseases.PLoS computational biology · 2025Review
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Association Between Wnt Target Genes and Cortical Volumes in Alzheimer's Disease.Journal of molecular neuroscience : MN · 2023Article
- Review
- Network Tau spreading is vulnerable to the expression gradients ofScience translational medicine · 2022Article
- Identifying Alzheimer's genes via brain transcriptome mapping.BMC medical genomics · 2022Article
- Graph Models of Pathology Spread in Alzheimer's Disease: An Alternative to Conventional Graph Theoretic Analysis.Brain connectivity · 2021Review
- Combined Model of Aggregation and Network Diffusion Recapitulates Alzheimer's Regional Tau-Positron Emission Tomography.Brain connectivity · 2021Article
- The human connectome in Alzheimer disease - relationship to biomarkers and genetics.Nature reviews. Neurology · 2021Review
- Network-constrained technique to characterize pathology progression rate in Alzheimer's disease.Brain communications · 2021Article
- Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease.Nature communications · 2020Article
- Origins of atrophy in Parkinson linked to early onset and local transcription patterns.Brain communications · 2020Article
- Neuropathology of the Alzheimer's continuum: an update.Free neuropathology · 2020Article
- Network mediation of pathology pattern in sporadic Creutzfeldt-Jakob disease.Brain communications · 2020Article
- Differences in topological progression profile among neurodegenerative diseases from imaging data.eLife · 2019Article
- Models of Network Spread and Network Degeneration in Brain Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease.NeuroImage. Clinical · 2018Article
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4 authors.
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Abstract
introductionThe stereotypical progression of Alzheimer's disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non-cell autonomous) processes.
methodsUsing mathematical and statistical models, we analyzed the contribution of cell-autonomous and non-cell autonomous factors to predictive linear models of AD pathology.
resultsResults indicate gene expression as a weak contributor to predictive linear models of AD. Instead, the network diffusion model acts as a strong predictor of observed AD atrophy and hypometabolism. DISCUSSION: We propose a convenient methodology for identifying genes and their role in determining AD topography, in comparison with network spread. Results reinforce the role of transneuronal network spread on disease progression and suggest that innate gene expression plays a secondary role in seeding and subsequent disease progression.
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