Evidence map›Paper›PMID 29306048›Full record

ArticleMagnetic resonance imaging2018

Comparison of cumulant expansion and q-space imaging estimates for diffusional kurtosis in brain.

Vaibhav Mohanty, Emilie T McKinnon, Joseph A Helpern, Jens H Jensen

Abstract readComparative Study
In one paragraph

Article in Magnetic resonance imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vaibhav MohantyCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
Emilie T McKinnonCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Joseph A HelpernCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Jens H JensenCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA. Electronic address: jense@musc.edu.

Funding

TRAINING PROGRAM FOR MEDICAL SCIENTISTST32GM008716 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEMORE, NANCY · 1999 to 2024
$9.3M
Interdisciplinary Research Training in Otolaryngology and Communication SciencesT32DC014435 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 2015 to 2024
$2.9M
NIDCD NIH HHS T32 DC014435NIGMS NIH HHS T32 GM008716
6 · The paper itself

Abstract

purposeTo compare estimates for the diffusional kurtosis in brain as obtained from a cumulant expansion (CE) of the diffusion MRI (dMRI) signal and from q-space (QS) imaging. THEORY AND

methodsFor the CE estimates of the kurtosis, the CE was truncated to quadratic order in the b-value and fit to the dMRI signal for b-values from 0 up to 2000s/mm

resultsThe whole brain mean values for the CE and QS kurtosis estimates differed by 16% or less in each of the considered diffusion encoding directions, and the Pearson correlation coefficients all exceeded 0.85. Nonetheless, there were large discrepancies in many voxels, particularly those with either very high or very low kurtoses relative to the mean values.

conclusionEstimates of the diffusional kurtosis in brain obtained using CE and QS approximations are strongly correlated, suggesting that they encode similar information. However, for the choice of b-values employed here, there may be substantial differences, depending on the properties of the diffusion microenvironment in each voxel.

Indexed as

BrainDiffusion Magnetic Resonance ImagingHumansImage Processing, Computer-AssistedMaleMiddle AgedReference ValuesReproducibility of ResultsAccuracyBrainCumulant expansionDiffusion MRIKurtosisQ-space imaging

Identifiers

PMID29306048
PMCPMC5889972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.