ArticleBone2018
Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing.
Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Synchronizing degradation with regeneration: a model-driven framework for designing biodegradable biomaterials in bone tissue engineering.Journal of materials science. Materials in medicine · 2026Review
- Magnesium degradation-induced variable fixation plates promote the vascularization of femoral fracture in rabbits.Journal of orthopaedic surgery and research · 2026Article
- Smart exoskeleton-assisted rehabilitation after fracture surgery: closed-loop control, personalized load management, and integrated telemonitoring.Frontiers in bioengineering and biotechnology · 2026Review
- Finite element andFrontiers in bioengineering and biotechnology · 2026Article
- The sobol sensitivity analysis of the pressure, stresses, and displacement arising from poroelastic modelling of hard mechanical systems.Scientific reports · 2025Article
- Total flavonoids of rhizoma drynariae improved the osteogenic and pro-angiogenic capacities of BMSCs to accelerate long bone regeneration.Scientific reports · 2025Article
- Exenatide, a glucagon-like peptide-1 receptor agonist, may negatively impact bone healing in rats: histopathological, biochemical, and in silico findings.Journal of orthopaedic surgery and research · 2025Article
- Article
- Magnesium degradation-induced variable fixation plates promote bone healing in rabbits.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024Article
- Review
- PeriostinBone research · 2024Article
- Delayed Union and Nonunion: Current Concepts, Prevention, and Correction: A Review.Bioengineering (Basel, Switzerland) · 2024Review
- Biomechanical analysis of combi-hole locking compression plate during fracture healing: A numerical study of screw configuration.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024Article
- Promoting bone callus formation by taking advantage of the time-dependent fracture gap strain modulation.Frontiers in surgery · 2024Review
- Estrogen deficiency impedes fracture healing despite eliminating the excessive absorption of the posterior callus in a semi-fixed distal tibial fracture mouse model.BMC musculoskeletal disorders · 2023Article
- Bone disease imaging through the near-infrared-II window.Nature communications · 2023Article
- Synergistic effect of sulfonation followed by precipitation of amorphous calcium phosphate on the bone-bonding strength of carbon fiber reinforced polyetheretherketone.Scientific reports · 2023Article
- Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair.Stem cell reports · 2022Article
- Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.Science advances · 2022Article
- Postnatal Osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
Mechanical loading is an important aspect of post-surgical fracture care. The timing of load application relative to the injury event may differentially regulate repair depending on the stage of healing. Here, we used a novel mechanobiological model of cortical defect repair that offers several advantages including its technical simplicity and spatially confined repair program, making effects of both physical and biological interventions more easily assessed. Using this model, we showed that daily loading (5N peak load, 2Hz, 60 cycles, 4 consecutive days) during hematoma consolidation and inflammation disrupted the injury site and activated cartilage formation on the periosteal surface adjacent to the defect. We also showed that daily loading during the matrix deposition phase enhanced both bone and cartilage formation at the defect site, while loading during the remodeling phase resulted in an enlarged woven bone regenerate. All loading regimens resulted in abundant cellular proliferation throughout the regenerate and fibrous tissue formation directly above the defect demonstrating that all phases of cortical defect healing are sensitive to physical stimulation. Stress was concentrated at the edges of the defect during exogenous loading, and finite element (FE)-modeled longitudinal strain (ε
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.