Trial reportMetabolism: clinical and experimental2018
A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.
Trial report in Metabolism: clinical and experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The Relationship between Whole-Grain Intake and Measures of Cognitive Decline, Mood, and Anxiety-A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- The crucial role and mechanism of insulin resistance in metabolic disease.Frontiers in endocrinology · 2023Pooled it
- Effects of whole grain intake on glycemic control: A meta-analysis of randomized controlled trials.Journal of diabetes investigation · 2022Pooled it
- Whole-Grain Consumption Does Not Affect Obesity Measures: An Updated Systematic Review and Meta-analysis of Randomized Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Whole grain food diet slightly reduces cardiovascular risks in obese/overweight adults: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Mediterranean Diet Pyramid: A Proposal for Italian People. A Systematic Review of Prospective Studies to Derive Serving Sizes.Nutrients · 2019Pooled it
- Food groups and intermediate disease markers: a systematic review and network meta-analysis of randomized trials.The American journal of clinical nutrition · 2018Pooled it
- A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.Molecular nutrition & food research · 2019Trial
- Combined Short-Chain Fatty Acids Induce an Anti-Inflammatory and Anti-Chemotactic Secretory Profile from 3T3-L1 Adipocytes in Normoxic and Hypoxic Environmental Conditions.International journal of molecular sciences · 2026Article
- Severity of Hypoxia-Induced Effects on 3T3-L1 Adipocyte Secretory Function Is Attenuated Dose-Dependently by Individual Short-Chain Fatty Acids.Nutrients · 2026Article
- Association between the diabetes risk reduction diet and polycystic ovary syndrome.BMC nutrition · 2026Article
- Evaluation of the Predominant Dietary Pattern and Sleep Disorders in Obese Diabetic Patients and Non-diabetic Obese Individuals : Short title: The Dietary Pattern and Sleep Disorders in Diabetics.Galen medical journal · 2026Article
- Isocaloric substitution with beef and mutton and metabolically unhealthy obesity among adults in Ordos, Inner Mongolia: a cross-sectional analysis.Frontiers in nutrition · 2026Article
- Physicochemical and Functional Properties of Soluble and Insoluble Dietary Fibers in Whole Grains and Their Health Benefits.Foods (Basel, Switzerland) · 2025Review
- Article
- Dose-Dependent Effects of Short-Chain Fatty Acids on 3T3-L1 Adipocyte Adipokine Secretion and Metabolic Function.Nutrients · 2025Article
- Trend and age-period-cohort analysis of colorectal cancer burden attributable to low whole grains intake: a global, regional, and national analysis with predictive modeling (1990-2046).Frontiers in nutrition · 2025Article
- Nutritional and sensory enhancement of traditional wheat-based yeasted steamed dumplings through oat flour fortification.Frontiers in nutrition · 2025Article
- Supplementation of a High-Fat Diet with Pentadecylresorcinol Increases the Representation ofInternational journal of molecular sciences · 2024Article
- Comparison of food intake pattern of diabetic patients and healthy individuals in a sample of Saudi population: a case-control study.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundWhole-grain intake is associated with lower risk of type 2 diabetes but the mechanisms are unclear. PURPOSE: We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet.
methodsA double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38 ± 2 y; BMI, 34.0 ± 1.1 kg/m
resultsPost-prandial glucose tolerance, peripheral insulin sensitivity, and metabolic flexibility (insulin-stimulated - fasting carbohydrate oxidation) improvements were greater after whole-grain compared to the refined-grain diet (P < 0.05). Compared to baseline, body fat (~2 kg) and hepatic R
conclusionWhole-grains reduced diabetes risk and the mechanisms appear to work through reduced post-prandial blood glucose and peripheral insulin resistance that were statistically linked to enhanced metabolic flexibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.