ArticleNeurochemistry international2018
Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster.
Article in Neurochemistry international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Motor neurons integrate cholinergic inputs through spatial organization of diverse nicotinic receptors.PNAS nexus · 2026Article
- Behavioral disruption in honey bees (Apis mellifera) exposed to isolated and combined insecticides.Ecotoxicology (London, England) · 2026Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Thiamethoxam at environmentally relevant concentrations induces neurotoxicity in zebrafish larvae through binding with multiple receptors.Eco-Environment & Health · 2025Article
- A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG.PLoS genetics · 2024Article
- Comparative analysis of tardigrade locomotion across life stage, species, and disulfiram treatment.PloS one · 2024Article
- Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity.BMC medical genomics · 2023Article
- Expression of subunits of an insecticide target receptor varies across tissues, life stages, castes, and species of social bees.Molecular ecology · 2023Article
- Fast-Scan Cyclic Voltammetry (FSCV) Reveals Behaviorally Evoked Dopamine Release by Sugar Feeding in the Adult Drosophila Mushroom Body.Angewandte Chemie (International ed. in English) · 2022Article
- SSRI antidepressants differentially modulate serotonin reuptake and release in Drosophila.Journal of neurochemistry · 2022Article
- Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.Biology open · 2021Article
- Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors inFrontiers in cellular neuroscience · 2021Review
- Ring Finger Protein 11 (RNF11) Modulates Dopamine Release in Drosophila.Neuroscience · 2021Article
- Real-Time Measurement of Stimulated Dopamine Release in Compartments of the AdultAnalytical chemistry · 2020Article
- Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson's Disease is Mediated by α7-Nicotinic Receptors.International journal of molecular sciences · 2020Article
- Measurement of natural variation of neurotransmitter tissue content in red harvester ant brains among different colonies.Analytical and bioanalytical chemistry · 2020Article
- Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference.Molecular neurobiology · 2019Article
- The novel pesticide flupyradifurone (Sivanto) affects honeybee motor abilities.Ecotoxicology (London, England) · 2019Article
- Electrochemical Measurements of Acetylcholine-Stimulated Dopamine Release in Adult Drosophila melanogaster Brains.Analytical chemistry · 2018Article
- Drosophila as a Model System for Neurotransmitter Measurements.ACS chemical neuroscience · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acetylcholine is an excitatory neurotransmitter in the central nervous system of insects and the nicotinic acetylcholine receptor (nAChR) is a target for neonicotinoid insecticides. Functional insect nAChRs are difficult to express in host cells, and hence difficult to study. In mammals, acetylcholine and nicotine evoke dopamine release, but the extent to which this mechanism is conserved in insects is unknown. In intact larval ventral nerve cords (VNCs), we studied dopamine evoked by acetylcholine, nicotine, or neonicotinoids. Using fast-scan cyclic voltammetry, we confirmed dopamine was measured by its cyclic voltammogram and also by feeding Drosophila the synthesis inhibitor, 3-iodotyrosine, which lowered the evoked dopamine response. Acetylcholine (1.8 pmol) evoked on average 0.43 ± 0.04 μM dopamine. Dopamine release significantly decreased after incubation with α-bungarotoxin, demonstrating the release is mediated by nAChR, but atropine, a muscarinic AChR antagonist, had no effect. Nicotine (t
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.